Smith Charles D
Alzheimer's Disease Center, Sanders-Brown Center on Aging, University of Kentucky, USA.
Biochim Biophys Acta. 2012 Mar;1822(3):317-24. doi: 10.1016/j.bbadis.2011.07.002. Epub 2011 Jul 14.
In this review focus is on structural imaging in the Alzheimer's disease (AD) pre-states, particularly cognitively normal (CN) persons at future dementia risk. Findings in mild cognitive impairment (MCI) are described here only for comparison with CN. Cited literature evidence and commentary address issues of structural imaging alterations in CN that precede MCI and AD, regional patterns of such alterations, and the time relationship between structural imaging alterations and the appearance of symptoms of AD, issues relevant to the conduct of future AD prevention trials. This article is part of a Special Issue entitled: Imaging Brain Aging and Neurodegenerative disease.
本综述聚焦于阿尔茨海默病（AD）前驱期的结构成像，尤其是未来有患痴呆症风险的认知正常（CN）个体。轻度认知障碍（MCI）的研究结果仅在此处描述，以便与CN进行比较。引用的文献证据和评论涉及CN中先于MCI和AD出现的结构成像改变问题、此类改变的区域模式，以及结构成像改变与AD症状出现之间的时间关系，这些问题与未来AD预防试验的开展相关。本文是名为“脑老化与神经退行性疾病成像”特刊的一部分。
