兴奋剂药物对功能失调性情绪处理的衰减作用：ADHD 青少年的 fMRI 研究。
The attenuation of dysfunctional emotional processing with stimulant medication: an fMRI study of adolescents with ADHD.
机构信息
Columbia College of Physicians and Surgeons, New York, NY, USA.
出版信息
Psychiatry Res. 2011 Sep 30;193(3):151-60. doi: 10.1016/j.pscychresns.2011.02.005. Epub 2011 Jul 22.
Abstract
Functional neuroimaging studies of attention-deficit/hyperactivity disorder (ADHD) have focused on the neural correlates of cognitive control. However, for many youths with ADHD, emotional lability is an important clinical feature of the disorder. We aimed to identify the neural substrates associated with emotional lability that were distinct from impairments in cognitive control and to assess the effects that stimulants have on those substrates. We used functional magnetic resonance imaging (fMRI) to assess neural activity in adolescents with (N=15) and without (N=15) ADHD while they performed cognitive and emotional versions of the Stroop task that engage cognitive control and emotional processing, respectively. The participants with ADHD were scanned both on and off stimulant medication in a counterbalanced fashion. Controlling for differences in cognitive control, we found that during the emotional Stroop task, adolescents with ADHD as compared with controls demonstrated atypical activity in the medial prefrontal cortex (mPFC). Stimulants attenuated activity in the mPFC to levels comparable with controls.
摘要
注意缺陷多动障碍（ADHD）的功能神经影像学研究集中于认知控制的神经相关性。然而，对于许多患有 ADHD 的年轻人来说，情绪不稳定是该疾病的一个重要临床特征。我们旨在确定与认知控制损伤不同的与情绪不稳定相关的神经基础，并评估兴奋剂对这些基础的影响。我们使用功能磁共振成像（fMRI）来评估患有（N=15）和不患有（N=15）ADHD 的青少年在分别参与认知和情绪 Stroop 任务时的神经活动，这两个任务分别涉及认知控制和情绪处理。ADHD 患者以平衡的方式在服用兴奋剂和不服用兴奋剂的情况下进行扫描。在控制认知控制差异的情况下，我们发现，在情绪 Stroop 任务中，与对照组相比，ADHD 青少年的内侧前额叶皮层（mPFC）表现出异常活动。兴奋剂使 mPFC 的活动减弱到与对照组相当的水平。
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