对X染色体失活至关重要的人类Xist RNA A重复四环发夹的¹H、¹³C、¹⁵N和³¹P化学位移归属
¹H, ¹³C, ¹⁵N and ³¹P chemical shift assignments of a human Xist RNA A-repeat tetraloop hairpin essential for X-chromosome inactivation.
作者信息
Duszczyk Malgorzata M, Sattler Michael
机构信息
Institute of Structural Biology, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany.
出版信息
Biomol NMR Assign. 2012 Apr;6(1):75-7. doi: 10.1007/s12104-011-9328-z. Epub 2011 Jul 21.
PMID:21779925
Abstract
Initiation of X-chromosome inactivation in female mammals depends on the non-coding RNA Xist. We have solved the NMR structure of a 14-nucleotide hairpin with a novel AUCG tetraloop fold from a Xist A-repeat that is essential for silencing. The (1)H, (13)C, (15)N and (31)P chemical shift assignments are reported.
摘要
雌性哺乳动物中X染色体失活的起始依赖于非编码RNA Xist。我们解析了一种来自Xist A重复序列的具有新型AUCG四环折叠的14核苷酸发夹的核磁共振结构，该结构对于沉默至关重要。报告了氢、碳-13、氮-15和磷-31的化学位移归属。
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