RGS5 表达与非小细胞肺癌的癌症分化和转移之间的关系。

The relationship between RGS5 expression and cancer differentiation and metastasis in non-small cell lung cancer.

机构信息

Medical Oncology Department of Jinling Hospital, Medical School of Nanjing University, Nanjing, PR China.

出版信息

J Surg Oncol. 2012 Mar 15;105(4):420-4. doi: 10.1002/jso.22033. Epub 2011 Jul 20.

DOI:10.1002/jso.22033

PMID:21780128

Abstract

BACKGROUND

Regulator of G-protein signaling 5 (RGS5), a tissue-specific signal regulating molecular, plays important roles in the development of vasculature. Recently, we have found that the mRNA level of RGS5 was oppositely related with tumor metastasis in non-small cell lung cancer (NSCLC). However, the distribution of RGS5 in NSCLC and its significance need further study. We therefore investigated the expression of RGS5 in NSCLC, as well as its relationship with clinicopathologic parameters.

METHODS

Tumor tissues from 51 NSCLC patients were analyzed and expression of RGS5 in tumor tissues was examined by immunohistochemistry. Chi-square test (or Fisher's exact test), Breslow test and multivariate Cox regression model were performed for statistical analysis.

RESULTS

RGS5 were highly expressed in 47% (24/51) of NSCLC specimens. Expression of RGS5 was associated with tumor cell differentiation in NSCLC and low expression of RGS5 was strongly associated with cancer vasculature invasion and lymph node metastasis in NSCLC. Patients with high RGS5 expression in NSCLC had a prolonged progression free survival (15.0 months (95%CI: 6.1-23.9) vs. 6.0 months (95%CI: 1.3-10.7), P = 0.030).

CONCLUSION

RGS5 might be involved in cancer differentiation and metastasis in NSCLC. And it might be a candidate prognostic marker for PFS in NSCLC.

摘要

背景

G 蛋白信号调节因子 5（RGS5）是一种组织特异性信号调节分子，在血管发育中发挥重要作用。最近，我们发现 RGS5 的 mRNA 水平与非小细胞肺癌（NSCLC）的肿瘤转移呈负相关。然而，RGS5 在 NSCLC 中的分布及其意义需要进一步研究。因此，我们研究了 RGS5 在 NSCLC 中的表达及其与临床病理参数的关系。

方法

分析 51 例 NSCLC 患者的肿瘤组织，采用免疫组织化学法检测 RGS5 在肿瘤组织中的表达。采用卡方检验（或 Fisher 确切概率法）、Breslow 检验和多因素 Cox 回归模型进行统计学分析。

结果

在 51 例 NSCLC 标本中，RGS5 高表达率为 47%（24/51）。RGS5 的表达与 NSCLC 中肿瘤细胞分化有关，RGS5 低表达与 NSCLC 中的肿瘤血管浸润和淋巴结转移密切相关。RGS5 在 NSCLC 中高表达的患者无进展生存期（PFS）延长（15.0 个月（95%CI：6.1-23.9）vs. 6.0 个月（95%CI：1.3-10.7），P=0.030）。