Department of Biomedical Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.
Lung Cancer Research Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.
Cells. 2021 Jun 4;10(6):1383. doi: 10.3390/cells10061383.
The ubiquitin-mediated degradation system is responsible for controlling various tumor-promoting processes, including DNA repair, cell cycle arrest, cell proliferation, apoptosis, angiogenesis, migration and invasion, metastasis, and drug resistance. The conjugation of ubiquitin to a target protein is mediated sequentially by the E1 (activating)‒E2 (conjugating)‒E3 (ligating) enzyme cascade. Thus, E2 enzymes act as the central players in the ubiquitination system, modulating various pathophysiological processes in the tumor microenvironment. In this review, we summarize the types and functions of E2s in various types of cancer and discuss the possibility of E2s as targets of anticancer therapeutic strategies.
泛素介导的降解系统负责控制各种促进肿瘤的过程，包括 DNA 修复、细胞周期阻滞、细胞增殖、细胞凋亡、血管生成、迁移和侵袭、转移和耐药性。泛素与靶蛋白的连接是由 E1（激活）-E2（连接）-E3（连接）酶级联反应依次介导的。因此，E2 酶作为泛素化系统的核心参与者，调节肿瘤微环境中的各种病理生理过程。在这篇综述中，我们总结了 E2 在各种类型癌症中的类型和功能，并讨论了 E2 作为抗癌治疗策略靶点的可能性。
