Laboratoire de biologie Cellulaire et Moléculaire Faculté de Medecine Dentaire Monastir, Rue Avicenne 5000, Tunisia.
Phytother Res. 2012 Mar;26(3):387-91. doi: 10.1002/ptr.3540. Epub 2011 Jul 21.
The antioxidant and apoptotic activities of digallic acid, isolated from the fruits of Pistascia lentiscus, were investigated. The study demonstrated that digallic acid possessed pro-apoptotic effects, as shown by provoking DNA fragmentation of K562 cells. It also revealed a significant antioxidant potential and effective scavenging activity against 2,2-diphenyl-1-picrylhdrazyl (DPPH·) and O₂·⁻ radicals, and reduced cupric ions. We conclude that this integrated approach to apoptotic and antioxidant assessment may be useful to maximize the beneficial effects associated with using P. lentiscus derivatives as medicinal and dietary compounds.
从黄连木的果实中分离得到的双没食子酸的抗氧化和促凋亡活性。研究表明，双没食子酸具有促凋亡作用，表现为引起 K562 细胞的 DNA 片段化。它还显示出显著的抗氧化潜力和有效清除 2,2-二苯基-1-苦基肼基（DPPH·）和 O₂·⁻自由基以及还原铜离子的能力。我们得出结论，这种凋亡和抗氧化评估的综合方法可能有助于最大限度地发挥使用黄连木衍生物作为药用和膳食化合物的有益效果。
