Fatimi Saulat H, Bawany Samira A, Ashfaq Awais
Aga Khan University, Stadium Road, Karachi 74800, Pakistan.
J Med Case Rep. 2011 Jul 22;5:322. doi: 10.1186/1752-1947-5-322.
Ganglioneuroblastoma is a rare peripheral neuroblastic tumor that is derived from developing neuronal cells of the sympathetic nervous system, and is found mostly, but not exclusively, in babies and young children.
To the best of our knowledge, there have been no previously reported cases of ganglioneuroblastoma of the mediastinum from Pakistan. We present a case of ganglioneuroblastoma in an eight-year-old Pakistani Sindhi boy incidentally found to have a large posterior mediastinal mass that on biopsy initially looked like ganglioneuroma. He underwent successful excision of the mediastinal mass and remained stable post-operatively. Final pathology findings showed a ganglioneuroblastoma. He has remained free of symptoms on long-term follow-up.
The rarity of this tumor along with its almost exclusive occurrence in the pediatric population necessitates a thorough investigation of patients presenting with a symptomatic mass.
神经节神经母细胞瘤是一种罕见的外周神经母细胞瘤，起源于交感神经系统发育中的神经元细胞，主要（但并非仅）见于婴幼儿。
据我们所知，此前尚无巴基斯坦关于纵隔神经节神经母细胞瘤的报道。我们报告一例8岁巴基斯坦信德族男孩的神经节神经母细胞瘤病例，该男孩偶然发现后纵隔有一巨大肿块，活检最初看似神经节瘤。他接受了纵隔肿块的成功切除，术后情况稳定。最终病理结果显示为神经节神经母细胞瘤。长期随访中他一直无症状。
这种肿瘤的罕见性及其几乎仅发生于儿科人群的情况，使得对有症状肿块的患者进行全面检查成为必要。
