Radiation Biology Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority, Egypt.
Ecotoxicol Environ Saf. 2011 Nov;74(8):2324-9. doi: 10.1016/j.ecoenv.2011.06.016. Epub 2011 Jul 22.
The present study aimed to investigate the protective role of cinnamon extract against inflammatory and oxidative injuries in gamma irradiated rats. Rats were subjected to fractionated doses of gamma radiation. Cinnamon extract were daily administrated before starting irradiation and continued after radiation exposure. The results obtained revealed that the administration of cinnamon extract to irradiated rats significantly ameliorated the changes induced in liver antioxidant system; catalase, superoxide dismutase and glutathione peroxidase activities as well as reduced glutathione concentration. The liver's lipid peroxidation and protein oxidation indices were significantly decreased when compared with their equivalent values in irradiated rats. Furthermore, the changes induces in xanthine oxidoreductase system were significantly diminished. In addition, the changes in liver nitric oxide contents, serum tumor necrosis factor alpha and C-reactive protein levels were markedly improved. In conclusion, the administration of cinnamon extract might provide substantial protection against radiation-induced oxidative and inflammatory damages.
本研究旨在探讨肉桂提取物对伽马射线照射大鼠炎症和氧化损伤的保护作用。大鼠接受分次剂量的伽马射线照射。肉桂提取物在开始照射前每天给予，并在照射后继续给予。结果表明，肉桂提取物的给予显著改善了照射大鼠肝脏抗氧化系统的变化；过氧化氢酶、超氧化物歧化酶和谷胱甘肽过氧化物酶的活性以及还原型谷胱甘肽的浓度。与照射大鼠相比，肝脂质过氧化和蛋白质氧化指标显著降低。此外，黄嘌呤氧化还原酶系统的变化明显减少。此外，肝脏一氧化氮含量、血清肿瘤坏死因子-α和 C-反应蛋白水平的变化也得到显著改善。总之，肉桂提取物的给予可能为辐射诱导的氧化和炎症损伤提供实质性的保护。
