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Trends Immunol. 2011 Aug;32(8):350-7. doi: 10.1016/j.it.2011.04.009. Epub 2011 Jul 23.
Maintenance of circulating, functional neutrophils and their robust recruitment to tissues in response to injury and/or microbial infection are crucial for host defense. Equally important, although less well understood, are the processes for removal of these short-lived cells. Here, we review recent findings of novel neutrophil characteristics that determine removal. These neutrophil-derived signals, in turn, can shape the responses of other cells and surrounding tissues and promote a return to homeostasis. If not removed, dying neutrophils disintegrate and release phlogistic cargo that can further contribute to ongoing inflammation, tissue destruction, or autoimmunity.
维持循环中功能正常的中性粒细胞，并在受到损伤和/或微生物感染时将其大量募集到组织中，对于宿主防御至关重要。同样重要的是（尽管了解得较少），还有这些寿命较短的细胞的清除过程。在这里，我们综述了最近发现的决定中性粒细胞清除的新的中性粒细胞特性。反过来，这些由中性粒细胞衍生的信号可以影响其他细胞和周围组织的反应，并促进恢复到稳态。如果不被清除，死亡的中性粒细胞会崩解并释放出促炎物质，这可能进一步导致持续的炎症、组织破坏或自身免疫。
