Department of Animal Science, College of Agriculture and Biology, Shanghai JiaoTong University, Shanghai 201101, PR China.
Environ Toxicol Pharmacol. 2003 Apr;13(3):199-204. doi: 10.1016/S1382-6689(03)00002-4.
Serum fluoride, nitric oxide (NO), malondialdehyde (MDA) contents and superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) activities were determined in chicks treated with graded doses of sodium fluoride. Compared with chicks in the control group, in the groups treated with fluoride, serum NO and MDA levels largely increased, and the activities of SOD, GSH-Px, and CAT decreased, most of which changed significantly (P<0.05). Serum fluoride levels significantly and positively correlated with serum NO, MDA levels, respectively (P<0.05), and significantly and negatively with serum SOD, GSH-Px, CAT activities, respectively (P<0.05). The results indicated fluoride was associated with the elevated NO levels and the decreased activities of antioxidant enzymes and the deposit of lipid peroxides (LPO). We suggest the mechanism of fluoride injuring soft tissues as follows: fluoride causes excessive production of NO, LPO and oxygen free radicals, which can damage seriously the structure and function of soft tissues.
血清氟化物、一氧化氮（NO）、丙二醛（MDA）含量和超氧化物歧化酶（SOD）、过氧化氢酶（CAT）、谷胱甘肽过氧化物酶（GSH-Px）活性在给予不同剂量的氟化钠处理的雏鸡中被测定。与对照组的雏鸡相比，氟化物处理组的血清 NO 和 MDA 水平显著增加，SOD、GSH-Px 和 CAT 活性降低，其中大多数变化显著（P<0.05）。血清氟化物水平与血清 NO 和 MDA 水平呈显著正相关（P<0.05），与血清 SOD、GSH-Px 和 CAT 活性呈显著负相关（P<0.05）。结果表明，氟化物与升高的 NO 水平以及抗氧化酶活性的降低和脂质过氧化物（LPO）的沉积有关。我们提出氟化物损伤软组织的机制如下：氟化物导致过量的 NO、LPO 和氧自由基产生，这可能严重损害软组织的结构和功能。
