Haroosh Hazim J, Dong Yu, Jasim Shaimaa, Ramakrishna Seeram
School of Civil and Mechanical Engineering, Curtin University, Perth, WA 6845, Australia.
Department Biomedical Science, Murdoch University, Perth, WA 6150, Australia.
Materials (Basel). 2021 Sep 16;14(18):5344. doi: 10.3390/ma14185344.
Electrospinning is a flexible polymer processing method to produce nanofibres, which can be applied in the biomedical field. The current study aims to develop new electrospun hybrid nanocomposite systems to benefit the sustained release of hydrophilic drugs with hydrophobic polymers. In particular, electrospun hybrid materials consisting of polylactic acid (PLA):poly(-caprolactone) (PCL) blends, as well as PLA:PCL/halloysite nanotubes-3-aminopropyltriethoxysilane (HNT-ASP) nanocomposites were developed in order to achieve sustained release of hydrophilic drug tetracycline hydrochloride (TCH) using hydrophobic PLA:PCL nanocomposite membranes as a drug carrier. The impact of interaction between two commonly used drugs, namely TCH and indomethacin (IMC) and PLA:PCL blends on the drug release was examined. The drug release kinetics by fitting the experimental release data with five mathematical models for drug delivery were clearly demonstrated. The average nanofiber diameters were found to be significantly reduced when increasing the TCH concentration due to increasing solution electrical conductivity in contrast to the presence of IMC. The addition of both TCH and IMC drugs to PLA:PCL blends reduced the crystallinity level, glass transition temperature () and melting temperature () of PCL within the blends. The decrease in drug release and the impairment elimination for the interaction between polymer blends and drugs was accomplished by mobilising TCH into HNT-ASP for their embedding effect into PLA:PCL nanofibres. The typical characteristic was clearly identified with excellent agreement between our experimental data obtained and Ritger-Peppas model and Zeng model in drug release kinetics. The biodegradation behaviour of nanofibre membranes indicated the effective incorporation of TCH onto HNT-ASP.
静电纺丝是一种用于生产纳米纤维的灵活的聚合物加工方法，可应用于生物医学领域。当前的研究旨在开发新型的静电纺丝混合纳米复合体系，以利于亲水性药物与疏水性聚合物的持续释放。具体而言，开发了由聚乳酸（PLA）：聚（ε-己内酯）（PCL）共混物以及PLA：PCL/埃洛石纳米管-3-氨丙基三乙氧基硅烷（HNT-ASP）纳米复合材料组成的静电纺丝混合材料，以便使用疏水性PLA：PCL纳米复合膜作为药物载体来实现亲水性药物盐酸四环素（TCH）的持续释放。研究了两种常用药物TCH和吲哚美辛（IMC）之间的相互作用以及PLA：PCL共混物对药物释放的影响。通过将实验释放数据与五种药物递送数学模型进行拟合，清楚地展示了药物释放动力学。与IMC存在的情况相比，由于溶液电导率增加，当增加TCH浓度时，发现平均纳米纤维直径显著减小。将TCH和IMC两种药物添加到PLA：PCL共混物中会降低共混物中PCL的结晶度、玻璃化转变温度（）和熔点（）。通过将TCH转移到HNT-ASP中以使其嵌入PLA：PCL纳米纤维中，实现了药物释放的降低以及聚合物共混物与药物之间相互作用的损伤消除。在药物释放动力学方面，我们获得的实验数据与Ritger-Peppas模型和Zeng模型之间具有极好的一致性，从而清楚地确定了典型特征。纳米纤维膜的生物降解行为表明TCH有效地掺入了HNT-ASP中。
