Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720-3202, USA.
Curr Biol. 2011 Jul 26;21(14):R560-9. doi: 10.1016/j.cub.2011.06.019.
Eukaryotic cells generate a diversity of actin filament networks in a common cytoplasm to optimally perform functions such as cell motility, cell adhesion, endocytosis and cytokinesis. Each of these networks maintains precise mechanical and dynamic properties by autonomously controlling the composition of its interacting proteins and spatial organization of its actin filaments. In this review, we discuss the chemical and physical mechanisms that target distinct sets of actin-binding proteins to distinct actin filament populations after nucleation, resulting in the assembly of actin filament networks that are optimized for specific functions.
真核细胞在共同的细胞质中生成多种肌动蛋白丝网络，以最佳方式执行细胞运动、细胞黏附、胞吞作用和胞质分裂等功能。这些网络通过自主控制相互作用蛋白的组成和肌动蛋白丝的空间组织，维持着精确的机械和动态特性。在这篇综述中，我们讨论了化学和物理机制，这些机制可以将不同的肌动蛋白结合蛋白靶向到成核后的特定肌动蛋白丝群体，从而组装出针对特定功能进行了优化的肌动蛋白丝网络。
