Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, IL 60637, USA.
Trends Cell Biol. 2011 Mar;21(3):177-87. doi: 10.1016/j.tcb.2010.11.001. Epub 2010 Dec 7.
How the actin cytoskeleton assembles into different structures to drive diverse cellular processes is a fundamental cell biological question. In addition to orchestrating the appropriate combination of regulators and actin-binding proteins, different actin-based structures must insulate themselves from one another to maintain specificity within a crowded cytoplasm. Actin specification is particularly challenging in complex eukaryotes where a multitude of protein isoforms and actin structures operate within the same cell. Fission yeast Schizosaccharomyces pombe possesses a single actin isoform that functions in three distinct structures throughout the cell cycle. In this review we explore recent studies in fission yeast that help unravel how different actin structures operate in cells.
肌动蛋白细胞骨架如何组装成不同的结构来驱动不同的细胞过程，这是一个基本的细胞生物学问题。除了协调适当的调节剂和肌动蛋白结合蛋白组合外，不同的基于肌动蛋白的结构还必须相互隔离，以在拥挤的细胞质中保持特异性。在复杂的真核生物中，肌动蛋白的特异性尤其具有挑战性，因为在同一个细胞中存在多种蛋白质同工型和肌动蛋白结构。裂殖酵母 Schizosaccharomyces pombe 只拥有一种肌动蛋白同工型，它在整个细胞周期中发挥三种不同的结构功能。在这篇综述中，我们探讨了裂殖酵母的最新研究，这些研究有助于揭示不同的肌动蛋白结构如何在细胞中发挥作用。
