Department of Neurological Surgery, Division of Neuro-Oncology, University of California-San Francisco, San Francisco, CA 94143-0372, USA.
Cancer J. 2012 Jan-Feb;18(1):26-31. doi: 10.1097/PPO.0b013e318244d7c8.
Glioblastoma is the most common primary malignant brain tumor; standard initial treatment includes a combination of radiation and temozolomide, and treatment at recurrence often includes the use of antiangiogenic agents. Characterization of tumor at initial diagnosis, assessment of response, and ability to distinguish viable tumor from treatment effects are ongoing challenges in neuroimaging. Progress has been made with the new Response Assessment in Neuro-Oncology criteria, and new imaging modalities and combinations continue to be evaluated to further improve our ability to characterize glioblastomas at all points during their disease course.
胶质母细胞瘤是最常见的原发性恶性脑肿瘤；标准初始治疗包括放疗和替莫唑胺联合治疗，复发时的治疗通常包括抗血管生成药物的使用。在神经影像学中，肿瘤的初始诊断特征、治疗反应评估以及区分存活肿瘤与治疗效果的能力仍然是持续存在的挑战。新的神经肿瘤学反应评估标准取得了进展，新的成像方式和组合也在不断被评估，以进一步提高我们在胶质母细胞瘤病程的各个阶段对其进行特征描述的能力。
