Industrial Toxicology Research Centre, P.O. Box-80, M.G. Marg, Lucknow 226001, India.
Environ Toxicol Pharmacol. 2005 Feb;19(2):335-49. doi: 10.1016/j.etap.2004.09.003.
Exposure assessment is often considered the weakest link in risk assessment. It is important for investigators to continue to utilize the full potential of biomarkers for chemicals whose exposure is of global concern. This review is concerned with the biomarkers of metal toxicity, as the overall exposure to metals encountered occupationally or in the environment would continue causing indirect, delayed effects therefore ecoepidemiology, using designed molecular probes and noninvasive diagnostics will be the leading component for future management of environmental health. An attempt is made here at appraising the need for the development of more biomarkers for use in environmental epidemiology and health risk assessment.
暴露评估通常被认为是风险评估中最薄弱的环节。对于研究人员来说，继续利用生物标志物来评估那些暴露于全球关注的化学物质的潜在风险非常重要。本篇综述关注金属毒性的生物标志物，因为总体上职业暴露或环境中接触的金属会持续造成间接的、延迟的影响，因此生态流行病学，利用设计的分子探针和非侵入性诊断，将成为未来环境健康管理的主要组成部分。在这里，我们试图评估在环境流行病学和健康风险评估中开发更多生物标志物的必要性。
