柚皮素和铅对大鼠红细胞碳酸酐酶的影响。
Effects of Naringenin and Lead on Rat Erythrocyte Carbonic Anhydrase Enzyme.
作者信息
Kuzu Müslüm, Özkaya Ahmet, Şahin Zafer, Dağ Üzeyir, Çomakli Veysel, Demirdağ Ramazan
机构信息
Ağrı İbrahim Çeçen University, Faculty of Pharmacy, Ağrı, Turkey.
Adıyaman University, Faculty of Arts and Sciences, Department of Chemistry, Adıyaman, Turkey.
出版信息
Turk J Pharm Sci. 2017 Apr;14(1):9-12. doi: 10.4274/tjps.13008. Epub 2017 Apr 15.
OBJECTIVES
Carbonic anhydrase (CA) enzyme catalyses the reversible reactions of CO with water and takes part in metabolically important events such as systemic acid-base regulation and respiration. In this study, effects of lead, which is a heavy metal and to which living beings are exposed by different ways, with naringenin, a flavanone, were investigated.
MATERIALS AND METHODS
For this purpose, four different rat groups were established and one of them was chosen as the control group. The other three groups were given lead, naringenin and lead+naringenin substances to analyze the changes in the CA enzyme of rat erythrocytes.
RESULTS
The research findings showed that the enzyme activity in the control group was higher than that in the other groups. The naringenin group showed the highest inhibition effect, while the lead group showed the lowest inhibition.
CONCLUSION
Therefore, it can be said that naringenin is a strong inhibitor of the CA enzyme.
目的
碳酸酐酶（CA）催化二氧化碳与水的可逆反应，并参与诸如全身酸碱调节和呼吸等重要代谢过程。在本研究中，研究了生物以不同方式接触的重金属铅与黄酮类化合物柚皮素的作用。
材料与方法
为此，设立了四个不同的大鼠组，其中一组选为对照组。另外三组分别给予铅、柚皮素和铅 + 柚皮素物质，以分析大鼠红细胞中CA酶的变化。
结果
研究结果表明，对照组的酶活性高于其他组。柚皮素组显示出最高的抑制作用，而铅组显示出最低的抑制作用。
结论
因此，可以说柚皮素是CA酶的强效抑制剂。
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