Institute of Marine Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, PR China.
Environ Toxicol Pharmacol. 2007 Sep;24(2):122-8. doi: 10.1016/j.etap.2007.04.002. Epub 2007 Apr 19.
The aim of this study was to investigate the natural role of the mantle in pearl oyster, Pinctada fucata. The mantle is believed to be the tissue responsible for shell and pearl formation. However, our current study on lead and copper accumulation in tissues of the oyster showed that the secondary tissue for lead accumulation was not the digestive gland but the mantle. In view of high lead concentrations in the mantle, its general metabolic condition (including immune and antioxidant defense systems) as affected by the two metals was studied. The results indicated that activities of antioxidant enzymes (superoxide dismutase, SOD; Se-dependent glutathione peroxidase, Se-GPx) were altered by lead and copper in the similar way. However, the immune enzyme activities (acid phosphatase, AcPase; phenoloxidase, PO) were perturbed differently by two metals. Therefore, the mantle of P. fucata was predicted to participate in immune processes and accumulation or detoxification of lead besides shell formation. Our observations described here may also provide important clues to further understanding of the biomarker responses of bivalves.
本研究旨在探究珍珠贝（Pinctada fucata）外套膜的天然作用。外套膜被认为是形成贝壳和珍珠的组织。然而，我们目前关于牡蛎组织中铅和铜积累的研究表明，铅积累的次级组织不是消化腺，而是外套膜。鉴于外套膜中铅浓度较高，研究了这两种金属对外套膜一般代谢状况（包括免疫和抗氧化防御系统）的影响。结果表明，抗氧化酶（超氧化物歧化酶、SOD；硒依赖性谷胱甘肽过氧化物酶、Se-GPx）的活性被铅和铜以相似的方式改变。然而，两种金属对免疫酶活性（酸性磷酸酶、AcPase；酚氧化酶、PO）的影响不同。因此，预测珍珠贝的外套膜除了参与贝壳形成外，还参与免疫过程以及铅的积累或解毒。我们在这里描述的观察结果也可能为进一步了解双壳类动物的生物标志物反应提供重要线索。
