Department of Biochemistry and Biotechnology, Annamalai University, Annamalai Nagar 608002, Tamil Nadu, India.
Environ Toxicol Pharmacol. 2009 Jan;27(1):120-6. doi: 10.1016/j.etap.2008.09.004. Epub 2008 Sep 23.
The study examines the effects of taurine on the metabolism and detoxification of ethanol in liver fibrosis induced by simultaneous administration of iron carbonyl (0.5%, w/w) and ethanol (6g/(kgday)). Ethanol and iron administration caused liver damage and fibrosis as evidenced by liver histology and biochemical profile in plasma. Over accumulation of iron and a loss in taurine in hepatic tissue was observed in fibrotic animals. The activities of alcohol dehydrogenase and aldehyde dehydrogenase were significantly reduced in these rats compared to control. Adaptive induction of activities of Cytochrome P4502E1 (CYP2E1) and aniline hydroxylase accompanied by the reduction in glutathione-S-transferase, DT-diaphorase and glyoxalases I and II was observed. Taurine administration (2% in drinking water) ameliorated the effects of ethanol and iron. Hepatic damage and fibrosis were reduced in taurine-supplemented rats. Thus taurine has the potential for the treatment of alcoholic liver fibrosis.
本研究考察了牛磺酸对同时给予羰基铁（0.5%，w/w）和乙醇（6g/（kg·天））诱导的肝纤维化中乙醇的代谢和解毒的影响。乙醇和铁的给予导致肝损伤和纤维化，这可以通过肝组织学和血浆生化谱来证明。在纤维化动物中观察到肝组织中铁的过度积累和牛磺酸的丧失。与对照组相比，这些大鼠中醇脱氢酶和醛脱氢酶的活性显著降低。细胞色素 P4502E1（CYP2E1）和苯胺羟化酶的适应性诱导伴随着谷胱甘肽-S-转移酶、DT-二氢嘧啶酶和甘油醛酶 I 和 II 的减少。牛磺酸的给予（在饮用水中 2%）改善了乙醇和铁的作用。补充牛磺酸的大鼠肝损伤和纤维化减少。因此，牛磺酸具有治疗酒精性肝纤维化的潜力。
