Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, CEP 97105-900, RS, Brazil.
Environ Toxicol Pharmacol. 2009 Sep;28(2):280-7. doi: 10.1016/j.etap.2009.05.002. Epub 2009 May 14.
Alkynylselenoalcohol compounds were screened for in vitro antioxidant activity. Alkynylselenoalcohols (2a-2d) were tested against lipid and protein oxidation induced by sodium nitroprusside (SNP) in rat brain and liver. The influence of molecular structural modifications of alkynylselenoalcohols in their antioxidant activity was investigated. The 1,1'-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging activity and the interaction of alkynylselenoalcohols with iron were carried out. The results revealed that the antioxidant activity depends on their chemical structures. Compounds 2e (without hydroxyl group) and 3a (with a tellurium atom) presented better antioxidant profiles than 2b (with a hydroxyl group and selenium atom) against lipid and protein oxidation. Compound 1a (with a butyl group) did not modify the effect of compound 2a (with a phenyl group) on lipid oxidation. Compounds 2e and 3a showed DPPH radical-scavenging activity. Compounds 2b, 2c and 3a inhibited isocitrate-mediated oxidation of Fe(2+). Alkynylselenoalcohols demonstrated antioxidant effects and the modifications in the molecular structure of compound 2b improved its antioxidant potency.
炔基硒醇化合物被筛选用于体外抗氧化活性。在大鼠脑和肝中，炔基硒醇（2a-2d）被测试用于对抗亚硝基铁氰化钠（SNP）诱导的脂质和蛋白质氧化。研究了炔基硒醇分子结构修饰对其抗氧化活性的影响。进行了 1,1'-二苯基-2-苦基肼（DPPH）自由基清除活性和炔基硒醇与铁的相互作用。结果表明，抗氧化活性取决于它们的化学结构。与 2b（具有羟基和硒原子）相比，化合物 2e（无羟基）和 3a（含碲原子）对脂质和蛋白质氧化具有更好的抗氧化特性。化合物 1a（具有丁基）没有改变化合物 2a（具有苯基）对脂质氧化的影响。化合物 2e 和 3a 表现出 DPPH 自由基清除活性。化合物 2b、2c 和 3a 抑制异柠檬酸介导的 Fe(2+)氧化。炔基硒醇表现出抗氧化作用，化合物 2b 分子结构的修饰提高了其抗氧化能力。
