Department of Psychiatry, Teikyo University Chiba Medical Center, Ichihara, Japan.
PLoS One. 2013 May 22;8(5):e63756. doi: 10.1371/journal.pone.0063756. Print 2013.
The clinical outcome of antidepressant treatment in patients with major depressive disorder (MDD) is thought to be associated with personality traits. A number of studies suggest that depressed patients show high harm avoidance, low self-directedness and cooperativeness, as measured on the Temperament and Character Inventory (TCI). However, the psychology of these patients is not well documented.
Psychological evaluation using Cloninger's TCI, was performed on treatment-resistant MDD patients (n = 35), remission MDD patients (n = 31), and age- and gender-matched healthy controls (n = 174).
Treatment-resistant patients demonstrated high scores for harm avoidance, and low scores for reward dependence, self-directedness, and cooperativeness using the TCI, compared with healthy controls and remission patients. Interestingly, patients in remission continued to show significantly high scores for harm avoidance, but not other traits in the TCI compared with controls. Moreover, there was a significant negative correlation between reward dependence and harm avoidance in the treatment-resistant depression cohort, which was absent in the control and remitted depression groups.
This study suggests that low reward dependence and to a lesser extent, low cooperativeness in the TCI may be risk factors for treatment-resistant depression.
抗抑郁治疗在重度抑郁症（MDD）患者中的临床疗效被认为与人格特质有关。许多研究表明，抑郁患者在气质和性格量表（TCI）上表现出高回避、低自我导向和合作性。然而，这些患者的心理状态并没有得到很好的记录。
对 35 例治疗抵抗性 MDD 患者、31 例缓解性 MDD 患者和 174 名年龄和性别匹配的健康对照者进行了 Cloninger 的 TCI 心理评估。
与健康对照组和缓解组相比，治疗抵抗组的 TCI 回避得分较高，而奖赏依赖、自我导向和合作性得分较低。有趣的是，缓解组的患者继续表现出显著较高的回避得分，而在 TCI 中其他特质与对照组相比没有差异。此外，在治疗抵抗性抑郁症组中，奖赏依赖与回避之间存在显著的负相关，而在对照组和缓解组中则不存在这种相关性。
本研究表明，TCI 中的低奖赏依赖和在较小程度上的低合作性可能是治疗抵抗性抑郁症的危险因素。
