Instituto de Estudos em Saúde Coletiva, Universidade Federal do Rio de Janeiro, RJ, Brazil.
Ann Epidemiol. 2011 Nov;21(11):851-6. doi: 10.1016/j.annepidem.2011.06.004. Epub 2011 Jul 23.
We aimed to examine the relationship of birthweight to cognitive performance in middle aged participants of the Atherosclerosis Risk in Communities Study (ARIC).
Cognitive function, assessed by means of three neuropsychological tests-the Delayed Word Recall Test (DWR), the Digit Symbol Subtest of the Wechsler Adult Intelligence Scale-Revised (DSS/WAIS-R), and the Word Fluency (WF) Test, was evaluated in relation to birthweight, as recalled through standardized interviews, by the use of data from the second and fourth follow-up visits of the Atherosclerosis Risk in Communities study cohort (1990-1992 and 1996-1998, respectively). Overall, 6785 participants satisfied the inclusion criteria and were included in the analysis.
After adjusting for adult sociodemographic factors, childhood socioeconomic environment and parental risk factors, and adult anthropometric, health status-related. and behavioral variables, we observed linear trends for the relationship of birthweight to WF scores, although the trend was statistically significant only for those reporting exact birthweights (p for trend = .004). For the other cognitive test results, results were either null or inconsistent with the a priori hypotheses.
Except for WF in those reporting exact birthweights, our study does not support the notion that birthweight influences cognitive function in adults.
我们旨在研究社区动脉粥样硬化风险研究（ARIC）中中年参与者的出生体重与认知表现之间的关系。
使用 ARIC 研究队列的第二次和第四次随访（分别为 1990-1992 年和 1996-1998 年）的数据，通过标准化访谈回忆出生体重，并通过三种神经心理学测试（延迟单词回忆测试（DWR）、威斯勒成人智力量表修订版的数字符号子测试（DSS/WAIS-R）和单词流畅性（WF）测试）评估认知功能与出生体重的关系。总体而言，有 6785 名参与者符合纳入标准并纳入分析。
在调整了成人社会人口统计学因素、儿童社会经济环境和父母危险因素以及成人人体测量、健康状况相关和行为变量后，我们观察到出生体重与 WF 评分之间存在线性趋势，尽管对于报告确切出生体重的人，趋势在统计学上具有显著性（趋势检验的 p 值为.004）。对于其他认知测试结果，结果要么为零，要么与先验假设不一致。
除了报告确切出生体重的 WF 之外，我们的研究不支持出生体重影响成年人认知功能的观点。
