Peacock J M, Folsom A R, Knopman D S, Mosley T H, Goff D C, Szklo M
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, MN 55454-1015, USA.
Public Health Nutr. 2000 Sep;3(3):337-43. doi: 10.1017/s1368980000000380.
To assess the cross-sectional association of dietary and supplemental antioxidant (carotenoids, vitamins C and E) intake with cognitive function in 12 187 individuals, aged 48-67 years, participating in the Atherosclerosis Risk in Communities (ARIC) Study.
Dietary intake of antioxidant vitamins, as assessed by a food frequency questionnaire, and use of supplements were analysed in relation to the results of three cognitive tests, the delayed word recall test, the Wechsler adult intelligence scale, revised (WAIS-R) digit symbol subtest and the word fluency test.
After adjustment for covariates previously found to be associated with cognition in this sample, we found no consistent associations between dietary antioxidant vitamin intake or supplement use and any of the cognitive tests.
This study suggests little, if any, association between antioxidant vitamin intake and better cognitive function in middle-aged adults.
评估参与社区动脉粥样硬化风险（ARIC）研究的12187名年龄在48至67岁之间的个体的饮食和补充抗氧化剂（类胡萝卜素、维生素C和维生素E）摄入量与认知功能之间的横断面关联。
通过食物频率问卷评估抗氧化剂维生素的饮食摄入量，并分析补充剂的使用情况与三项认知测试结果的关系，这三项测试分别为延迟单词回忆测试、修订版韦氏成人智力量表（WAIS-R）数字符号子测试和单词流畅性测试。
在对先前发现与该样本认知相关的协变量进行调整后，我们发现饮食中抗氧化剂维生素摄入量或补充剂使用与任何一项认知测试之间均无一致的关联。
本研究表明，中年成年人抗氧化剂维生素摄入量与更好的认知功能之间几乎没有关联（如果有也很微弱）。
