Movement Disorders Section, Neuroscience Department, Institute for Neurological Research Raul Carrea (FLENI), Montañeses 2325, Ciudad Autonoma de Buenos Aires, Argentina.
Parkinsonism Relat Disord. 2011 Nov;17(9):705-7. doi: 10.1016/j.parkreldis.2011.07.002. Epub 2011 Jul 23.
While Movement Disorders Society Unified Parkinson's Disease rating scale (MDS-UPDRS) validation has been exhaustive; performance evaluation to detect acute changes arising after administration of a single dose of L-dopa has yet to be explored. To determine the correlation between UPDRS and MDS-UPDRS during the acute challenge with Ldopa and the MDS-UPDRS equivalent to 30% cutoff score of UPDRS for defining responsiveness, 64 patients were assessed. Consecutive assessments were performed immediately before and after administration of a single dose of L-dopa/carbidopa 250/25 mg using the motor section of the UPDRS and the MDS-UPDRS. Good diagnostic accuracy, consistent with published findings of high correlation between scales was observed. Area under the curve (AUC) was 0.99 (CI = 0.97-1.00, P < 0.001) and maximum Youden index (Y = 0.905) corresponded to a cutoff of 24.5%. In conclusion we have found an excellent correlation between UPDRS and MDS-UPDRS and that the 30% of variation in UPDRS score used for predicting sustained long term L-dopa response was equivalent to 24% in MDS-UPDRS.
虽然运动障碍协会统一帕金森病评定量表（MDS-UPDRS）的验证已经详尽无遗；但尚未探讨检测单次左旋多巴给药后急性变化的性能评估。为了确定 UPDRS 与 MDS-UPDRS 在急性 L-多巴挑战期间的相关性，以及与 UPDRS 定义反应性的 30%截止分数相当的 MDS-UPDRS ，评估了 64 名患者。使用 UPDRS 和 MDS-UPDRS 的运动部分，在单次给予左旋多巴/卡比多巴 250/25mg 之前和之后立即进行连续评估。观察到与高相关性的良好诊断准确性，与已发表的发现一致。曲线下面积（AUC）为 0.99（CI = 0.97-1.00，P <0.001），最大 Youden 指数（Y = 0.905）对应于 24.5%的截止值。总之，我们发现 UPDRS 和 MDS-UPDRS 之间具有极好的相关性，用于预测持续长期左旋多巴反应的 UPDRS 评分的 30%变化与 MDS-UPDRS 中的 24%相当。
