Keshavarzian A, Rizk G, Urban G, Willson C
Department of Medicine, Loyola University Medical School, Maywood, Illinois 60153.
Alcohol Clin Exp Res. 1990 Feb;14(1):76-81. doi: 10.1111/j.1530-0277.1990.tb00450.x.
Abnormal esophageal motility has been reported in alcoholics. This includes abnormally high esophageal contraction amplitudes (ECA) and elevated lower esophageal sphincter pressures (LESP). However, an animal model is lacking for evaluating the underlying mechanisms. To develop such a model of ethanol-induced esophageal motor dysfunction, esophageal manometry was done in control, chronically intoxicated, and withdrawing cats. Ethanol was administered for at least 30 days via gastrostomy tube and blood alcohol levels, typically 300 mg/dl, were adjusted to maintain inebriation. LESP and upper (striated muscle) and lower (smooth muscle) ECA were elevated in male withdrawing cats. In intoxicated cats only upper ECA was elevated. Surprisingly, LESP and ECA were not significantly affected in females. Duration of ECA was prolonged in both male and female intoxicated cats. These findings indicate that: (1) similar to withdrawing men, ECA and LESP are elevated in withdrawing male cats; (2) ethanol-treated cats are an appropriate model for studying the mechanism of ethanol effects on esophageal motor function; (3) gender has a significant role in influencing the effects of alcohol.
已有报道称酗酒者存在食管动力异常。这包括食管收缩幅度异常增高（ECA）以及食管下括约肌压力（LESP）升高。然而，目前尚缺乏用于评估其潜在机制的动物模型。为建立这样一种乙醇诱导的食管运动功能障碍模型，对对照组、长期酗酒组和戒酒组的猫进行了食管测压。通过胃造瘘管给予乙醇至少30天，并调整血酒精水平（通常为300mg/dl）以维持醉酒状态。戒酒的雄性猫的LESP以及上段（横纹肌）和下段（平滑肌）ECA均升高。在醉酒的猫中，仅上段ECA升高。令人惊讶的是，雌性猫的LESP和ECA未受到显著影响。醉酒的雄性和雌性猫的ECA持续时间均延长。这些发现表明：（1）与戒酒的男性相似，戒酒的雄性猫的ECA和LESP升高；（2）乙醇处理的猫是研究乙醇对食管运动功能影响机制的合适模型；（3）性别在影响酒精作用方面具有重要作用。
