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自闭症儿童粪便中黏液分解菌阿克曼氏菌和双歧杆菌属相对丰度较低。

Low relative abundances of the mucolytic bacterium Akkermansia muciniphila and Bifidobacterium spp. in feces of children with autism.

机构信息

Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, Australia.

出版信息

Appl Environ Microbiol. 2011 Sep;77(18):6718-21. doi: 10.1128/AEM.05212-11. Epub 2011 Jul 22.

DOI:10.1128/AEM.05212-11
PMID:21784919
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3187122/
Abstract

Gastrointestinal disturbance is frequently reported for individuals with autism. We used quantitative real-time PCR analysis to quantify fecal bacteria that could influence gastrointestinal health in children with and without autism. Lower relative abundances of Bifidobacteria species and the mucolytic bacterium Akkermansia muciniphila were found in children with autism, the latter suggesting mucus barrier changes.

摘要

胃肠道紊乱在自闭症患者中经常发生。我们使用定量实时 PCR 分析来定量粪便细菌，这些细菌可能会影响自闭症儿童和非自闭症儿童的胃肠道健康。自闭症儿童体内双歧杆菌属物种和黏液分解菌阿克曼氏菌的相对丰度较低，后者表明黏液屏障发生了变化。

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本文引用的文献

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Gastrointestinal flora and gastrointestinal status in children with autism--comparisons to typical children and correlation with autism severity.自闭症儿童的胃肠道菌群和胃肠道状况——与典型儿童的比较及与自闭症严重程度的相关性。
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Urinary p-cresol is elevated in small children with severe autism spectrum disorder.尿液对甲酚在患有严重自闭症谱系障碍的幼儿中升高。
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Alterations of the intestinal barrier in patients with autism spectrum disorders and in their first-degree relatives.自闭症谱系障碍患者及其一级亲属的肠道屏障改变。
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Mucolytic bacteria with increased prevalence in IBD mucosa augment in vitro utilization of mucin by other bacteria.在 IBD 黏膜中患病率增加的黏液溶解菌会增强其他细菌对黏液的体外利用。
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Urinary metabolic phenotyping differentiates children with autism from their unaffected siblings and age-matched controls.尿代谢组学分析可将自闭症患儿与其未受影响的兄弟姐妹及年龄匹配的对照组区分开来。
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Is urinary indolyl-3-acryloylglycine a biomarker for autism with gastrointestinal symptoms?尿吲哚基-3-丙烯酰基甘氨酸是否是伴胃肠道症状自闭症的生物标志物？
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Are there more bowel symptoms in children with autism compared to normal children and children with other developmental and neurological disorders?: A case control study.与正常儿童以及患有其他发育和神经障碍的儿童相比，自闭症儿童是否有更多肠道症状？一项病例对照研究。
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Intestinal mucus barrier in normal and inflamed colon.正常和发炎结肠中的肠道黏液屏障
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