Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea.
Diabetes Metab J. 2011 Jun;35(3):248-54. doi: 10.4093/dmj.2011.35.3.248. Epub 2011 Jun 30.
Chemerin is a novel adipokine that is associated with inflammation and adipogenesis. However, it remains unclear whether chemerin is involved in patients with cardiovascular disease. We investigated whether the serum chemerin levels of Korean patients with coronary artery disease correlated with specific cardiometabolic parameters.
In total, 131 patients, all of whom had coronary artery stenosis exceeding 50%, participated in this study. Their serum chemerin levels and cardiometabolic parameters were measured. The serum chemerin levels of two groups of patients were compared; those with one stenotic vessel (n=68) and those with multiple stenotic vessels, including left main coronary artery disease (n=63).
Serum chemerin levels correlated positively with the degree of coronary artery stenosis and fasting glucose, triglyceride, total cholesterol, low density lipoprotein cholesterol, and high sensitive C-reactive protein levels. The group with multiple stenotic vessels, including left main disease, had higher chemerin levels than the group with one stenotic vessel (t=-2.129, P=0.035). Multiple binary logistic regression showed chemerin was not an independent risk factor of multiple vessel disease (odds ratio, 1.018; confidence interval, 0.997 to 1.040; P=0.091).
Serum chemerin levels have a significant correlation with several cardiometabolic risk factors and the degree of coronary artery stenosis in Korean patients with coronary artery disease. However, multiple binary logistic regression showed chemerin was not an independent risk factor of multiple vessel disease. Additional investigations are necessary to fully elucidate the role of chemerin in cardiovascular disease.
趋化素是一种新型脂肪因子，与炎症和脂肪生成有关。然而，趋化素是否参与心血管疾病患者尚不清楚。我们研究了韩国冠状动脉疾病患者的血清趋化素水平是否与特定的心脏代谢参数相关。
共有 131 名患者参加了本研究，所有患者的冠状动脉狭窄均超过 50%。测量了他们的血清趋化素水平和心脏代谢参数。比较了两组患者的血清趋化素水平，一组为单一狭窄血管（n=68），另一组为包括左主干冠状动脉疾病在内的多个狭窄血管（n=63）。
血清趋化素水平与冠状动脉狭窄程度及空腹血糖、甘油三酯、总胆固醇、低密度脂蛋白胆固醇和高敏 C 反应蛋白水平呈正相关。包括左主干疾病在内的多支血管病变组的趋化素水平高于单支血管病变组（t=-2.129，P=0.035）。多元二项逻辑回归显示，趋化素不是多支血管疾病的独立危险因素（比值比，1.018；95%置信区间，0.997 至 1.040；P=0.091）。
血清趋化素水平与韩国冠状动脉疾病患者的几种心脏代谢危险因素和冠状动脉狭窄程度有显著相关性。然而，多元二项逻辑回归显示，趋化素不是多支血管疾病的独立危险因素。需要进一步研究以充分阐明趋化素在心血管疾病中的作用。
