Macvanin Mirjana T, Rizzo Manfredi, Radovanovic Jelena, Sonmez Alper, Paneni Francesco, Isenovic Esma R
Department of Radiobiology and Molecular Genetics, VINČA Institute of Nuclear Sciences-National Institute of the Republic of Serbia, University of Belgrade, 11000 Belgrade, Serbia.
Department of Internal Medicine and Medical Specialties (DIMIS), Università degli Studi di Palermo (UNIPA), 90128 Palermo, Italy.
Biomedicines. 2022 Nov 18;10(11):2970. doi: 10.3390/biomedicines10112970.
(1) Background: Obesity is closely connected to the pathophysiology of cardiovascular diseases (CVDs). Excess fat accumulation is associated with metabolic malfunctions that disrupt cardiovascular homeostasis by activating inflammatory processes that recruit immune cells to the site of injury and reduce nitric oxide levels, resulting in increased blood pressure, endothelial cell migration, proliferation, and apoptosis. Adipose tissue produces adipokines, such as chemerin, that may alter immune responses, lipid metabolism, vascular homeostasis, and angiogenesis. (2) Methods: We performed PubMed and MEDLINE searches for articles with English abstracts published between 1997 (when the first report on chemerin identification was published) and 2022. The search retrieved original peer-reviewed articles analyzed in the context of the role of chemerin in CVDs, explicitly focusing on the most recent findings published in the past five years. (3) Results: This review summarizes up-to-date findings related to mechanisms of chemerin action, its role in the development and progression of CVDs, and novel strategies for developing chemerin-targeting therapeutic agents for treating CVDs. (4) Conclusions: Extensive evidence points to chemerin's role in vascular inflammation, angiogenesis, and blood pressure modulation, which opens up exciting perspectives for developing chemerin-targeting therapeutic agents for the treatment of CVDs.
(1) 背景：肥胖与心血管疾病（CVDs）的病理生理学密切相关。脂肪过度积累与代谢功能紊乱有关，这些紊乱通过激活炎症过程破坏心血管稳态，炎症过程会将免疫细胞招募到损伤部位并降低一氧化氮水平，从而导致血压升高、内皮细胞迁移、增殖和凋亡。脂肪组织会产生诸如chemerin等脂肪因子，这些因子可能会改变免疫反应、脂质代谢、血管稳态和血管生成。(2) 方法：我们在PubMed和MEDLINE数据库中检索了1997年（第一篇关于chemerin鉴定的报告发表之年）至2022年间发表的带有英文摘要的文章。检索结果为在chemerin在心血管疾病中的作用背景下进行分析的原始同行评审文章，特别关注过去五年发表的最新研究结果。(3) 结果：本综述总结了与chemerin作用机制、其在心血管疾病发生和发展中的作用以及开发针对chemerin的治疗心血管疾病药物的新策略相关的最新研究结果。(4) 结论：大量证据表明chemerin在血管炎症、血管生成和血压调节中起作用，这为开发针对chemerin的治疗心血管疾病药物开辟了令人兴奋的前景。
