从针对 DC-SIGN 的 DNA 模板化片段文库中选择一种合成糖链寡聚物，并抑制 HIV gp120 与树突状细胞的结合。
Selection of a synthetic glycan oligomer from a library of DNA-templated fragments against DC-SIGN and inhibition of HIV gp120 binding to dendritic cells.
机构信息
Institut de Science et Ingenierie Supramoleculaires (ISIS), Université de Strasbourg-CNRS, 8 allee Gaspard Monge, 67000 Strasbourg, France.
出版信息
Chem Commun (Camb). 2011 Sep 7;47(33):9321-3. doi: 10.1039/c1cc13213j. Epub 2011 Jul 25.
We report the synthesis of a nucleic acid-encoded carbohydrate library, its combinatorial self-assembly into 37,485 pairs and a screen against DC-SIGN leading to the identification of consensus ligand motifs. A prototypical example from the selected pairs was shown to have enhanced binding. A dendrimer incorporating the selected motifs inhibited gp120's binding to dendritic cells with higher efficiency than mannan.
我们报告了一种核酸编码的碳水化合物文库的合成，其通过组合自身装配成 37485 对，并针对 DC-SIGN 进行了筛选，从而鉴定了共识配体基序。从选定的对中选择了一个原型示例，结果表明其结合增强。一种包含所选基序的树枝状大分子比甘露聚糖更有效地抑制 gp120 与树突状细胞的结合。
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