手性 N-叔丁基亚磺酰基 α,β-不饱和亚胺：一种简单高效的烯烃/亚磺酰胺混合配体，用于不对称 1,4-加成反应。
Chiral N-tert-butanesulfinyl α,β-unsaturated ketimine: a simple and highly effective olefin/sulfinimide hybrid ligand for asymmetric 1,4-additions.
机构信息
Beijing National Laboratory of Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.
出版信息
Org Biomol Chem. 2011 Sep 7;9(17):5927-9. doi: 10.1039/c1ob05971h. Epub 2011 Jul 25.
PMID:21785794
Abstract
One novel type of chiral olefin/sulfinimide hybrid ligands has been developed through a simple one-step condensation of α,β-unsaturated ketones with tert-butanesulfinamide and utilized successfully for rhodium-catalyzed asymmetric conjugated additions to furnish the desired adducts in high yields with excellent ee's.
摘要
一种新型的手性烯烃/亚磺酰胺混合配体已经通过α,β-不饱和酮与叔丁基亚磺酰胺的简单一步缩合反应开发出来，并成功用于铑催化的不对称共轭加成，以高产率和优异的对映选择性得到所需的加成产物。
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