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成功使用依那西普治疗瑞特综合征：病例报告及文献复习。

Successful use of etanercept for the treatment of Reiter's syndrome: a case report and review of the literature.

机构信息

University of Missouri-Kansas City, Kansas City, MO, USA.

出版信息

Rheumatol Int. 2012 Jan;32(1):1-3. doi: 10.1007/s00296-011-2000-1. Epub 2011 Jul 23.

DOI:10.1007/s00296-011-2000-1
PMID:21785961
Abstract

The treatment of severe and refractory cases of reactive arthritis is not well defined. There is a limited data about the use of tumor necrosis factor-α (TNF-α) blockers in reactive arthritis. Herein is a description of a patient with severe case of Chlamydia trachomatis-related reactive arthritis that was refractory to nonsteroidal anti-inflammatory drugs, sulfasalazine, prednisone, and methotrexate and was successfully treated with etanercept.

摘要

对于严重和难治性反应性关节炎病例，其治疗方法尚未明确。关于肿瘤坏死因子-α（TNF-α）阻滞剂在反应性关节炎中的应用，目前数据有限。本文描述了一例严重的衣原体相关反应性关节炎患者，该患者对非甾体抗炎药、柳氮磺胺吡啶、泼尼松和甲氨蝶呤均无反应，后使用依那西普成功治疗。

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本文引用的文献

1
Combination antibiotics as a treatment for chronic Chlamydia-induced reactive arthritis: a double-blind, placebo-controlled, prospective trial.联合使用抗生素治疗慢性衣原体诱导的反应性关节炎：一项双盲、安慰剂对照的前瞻性试验。
Arthritis Rheum. 2010 May;62(5):1298-307. doi: 10.1002/art.27394.
2
Reactive arthritis: clinical aspects and medical management.反应性关节炎：临床特征与药物治疗
Rheum Dis Clin North Am. 2009 Feb;35(1):21-44. doi: 10.1016/j.rdc.2009.03.010.
3
Infliximab for reactive arthritis secondary to Chlamydia trachomatis infection.
Int J Inflam. 2014;2014:158793. doi: 10.1155/2014/158793. Epub 2014 Jun 5.
4
Use of biologic agents in ocular manifestations of rheumatic disease.生物制剂在风湿性疾病眼部表现中的应用。
Int J Rheumatol. 2012;2012:203819. doi: 10.1155/2012/203819. Epub 2011 Dec 15.
英夫利昔单抗治疗沙眼衣原体感染相关性反应性关节炎。
Rheumatol Int. 2010 Mar;30(5):679-80. doi: 10.1007/s00296-009-0965-9. Epub 2009 May 23.
4
Successful use of infliximab in the treatment of Reiter's syndrome: a case report and discussion.英夫利昔单抗成功用于治疗赖特综合征：病例报告与讨论
Clin Rheumatol. 2008 Jan;27(1):121-3. doi: 10.1007/s10067-007-0692-0. Epub 2007 Jul 21.
5
Comparing 10-day and 4-month doxycycline courses for treatment of Chlamydia trachomatis-reactive arthritis: a prospective, double-blind trial.比较10天和4个月多西环素疗程治疗沙眼衣原体反应性关节炎：一项前瞻性双盲试验。
Ann Rheum Dis. 2006 Nov;65(11):1521-4. doi: 10.1136/ard.2005.045484.
6
Decreased pain and synovial inflammation after etanercept therapy in patients with reactive and undifferentiated arthritis: an open-label trial.依那西普治疗反应性关节炎和未分化关节炎患者后疼痛减轻及滑膜炎症改善：一项开放标签试验
Arthritis Rheum. 2005 Aug 15;53(4):613-7. doi: 10.1002/art.21323.
7
Alpha beta but not gamma delta T cell clones in synovial fluids of patients with reactive arthritis show active transcription of tumour necrosis factor alpha and interferon gamma.反应性关节炎患者滑液中的αβ而非γδ T细胞克隆显示肿瘤坏死因子α和干扰素γ的活跃转录。
Ann Rheum Dis. 2004 Dec;63(12):1673-6. doi: 10.1136/ard.2003.018192.
8
Three month treatment of reactive arthritis with azithromycin: a EULAR double blind, placebo controlled study.阿奇霉素治疗反应性关节炎三个月：一项欧洲抗风湿病联盟双盲、安慰剂对照研究。
Ann Rheum Dis. 2004 Sep;63(9):1113-9. doi: 10.1136/ard.2003.010710.
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Infliximab in the treatment of an HIV positive patient with Reiter's syndrome.英夫利昔单抗治疗一名患有赖特综合征的HIV阳性患者。
J Rheumatol. 2003 Feb;30(2):407-11.
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TNF involvement and anti-TNF therapy of reactive and unclassified arthritis.反应性关节炎和未分类关节炎中肿瘤坏死因子的参与及抗肿瘤坏死因子治疗
Clin Exp Rheumatol. 2002 Nov-Dec;20(6 Suppl 28):S130-4.