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类风湿关节炎。甲氨蝶呤治疗失败后三联疗法还是依那西普？

Rheumatoid arthritis. Triple therapy or etanercept after methotrexate failure in RA?

机构信息

Unit for Clinical Therapy Research, Inflammatory Diseases, The Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden.

出版信息

Nat Rev Rheumatol. 2013 Sep;9(9):510-2. doi: 10.1038/nrrheum.2013.118. Epub 2013 Jul 30.

DOI:10.1038/nrrheum.2013.118
PMID:23897440
Abstract

Since the 1990s, patients with rheumatoid arthritis have been treated with at least one DMARD. Methotrexate, which is usually the first-line treatment, elicits good or even excellent clinical results in 20–30% of patients—but in most patients it does not. Thus, an important question is what to do after methotrexate failure.

摘要

自 20 世纪 90 年代以来，类风湿关节炎患者至少接受过一种 DMARD 治疗。甲氨蝶呤通常是一线治疗药物，在 20%至 30%的患者中疗效良好甚至极佳，但在大多数患者中并非如此。因此，一个重要的问题是在甲氨蝶呤治疗失败后该怎么办。

相似文献

1
Rheumatoid arthritis. Triple therapy or etanercept after methotrexate failure in RA?类风湿关节炎。甲氨蝶呤治疗失败后三联疗法还是依那西普？
Nat Rev Rheumatol. 2013 Sep;9(9):510-2. doi: 10.1038/nrrheum.2013.118. Epub 2013 Jul 30.
2
Conventional triple therapy as good as etanercept for uncontrolled rheumatoid arthritis.传统三联疗法治疗未控制的类风湿性关节炎效果与依那西普相当。
BMJ. 2013 Jun 18;346:f3846. doi: 10.1136/bmj.f3846.
3
Therapies for active rheumatoid arthritis after methotrexate failure.甲氨蝶呤治疗失败后的活动性类风湿关节炎治疗方法。
N Engl J Med. 2013 Jul 25;369(4):307-18. doi: 10.1056/NEJMoa1303006. Epub 2013 Jun 11.
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Making rational treatment decisions in rheumatoid arthritis when methotrexate fails.甲氨蝶呤治疗失败时类风湿关节炎的合理治疗决策制定
N Engl J Med. 2013 Jul 25;369(4):384-5. doi: 10.1056/NEJMe1306381. Epub 2013 Jun 11.
5
A randomized comparative effectiveness study of oral triple therapy versus etanercept plus methotrexate in early aggressive rheumatoid arthritis: the treatment of Early Aggressive Rheumatoid Arthritis Trial.口服三联疗法与依那西普联合甲氨蝶呤治疗早期侵袭性类风湿关节炎的随机对照有效性研究：早期侵袭性类风湿关节炎治疗试验
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Triple therapy with non-biologic DMARDs for rheumatoid arthritis or biologic therapy. Is it the same?用于类风湿关节炎的非生物改善病情抗风湿药三联疗法或生物疗法。它们一样吗？
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Changes in lipoproteins associated with methotrexate or combination therapy in early rheumatoid arthritis: results from the treatment of early rheumatoid arthritis trial.早期类风湿关节炎中与甲氨蝶呤或联合治疗相关的脂蛋白变化：早期类风湿关节炎治疗试验的结果
Arthritis Rheum. 2013 Jun;65(6):1430-8. doi: 10.1002/art.37916.
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Advances in the medical management of rheumatoid arthritis.类风湿关节炎医学管理的进展
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Validation of the methotrexate-first strategy in patients with early, poor-prognosis rheumatoid arthritis: results from a two-year randomized, double-blind trial.甲氨蝶呤优先策略在早期预后不良类风湿关节炎患者中的验证：一项为期两年的随机双盲试验结果
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Progress in the treatment of rheumatoid arthritis.类风湿关节炎的治疗进展
JAMA. 2001 Dec 12;286(22):2787-90. doi: 10.1001/jama.286.22.2787.

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PLoS One. 2017 Jul 24;12(7):e0181782. doi: 10.1371/journal.pone.0181782. eCollection 2017.
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Is non-biological treatment of rheumatoid arthritis as good as biologics?类风湿关节炎的非生物治疗与生物制剂治疗效果一样好吗？
World J Orthop. 2015 Mar 18;6(2):278-83. doi: 10.5312/wjo.v6.i2.278.

本文引用的文献

1
Therapies for active rheumatoid arthritis after methotrexate failure.甲氨蝶呤治疗失败后的活动性类风湿关节炎治疗方法。
N Engl J Med. 2013 Jul 25;369(4):307-18. doi: 10.1056/NEJMoa1303006. Epub 2013 Jun 11.
2
A randomized comparative effectiveness study of oral triple therapy versus etanercept plus methotrexate in early aggressive rheumatoid arthritis: the treatment of Early Aggressive Rheumatoid Arthritis Trial.口服三联疗法与依那西普联合甲氨蝶呤治疗早期侵袭性类风湿关节炎的随机对照有效性研究：早期侵袭性类风湿关节炎治疗试验
Arthritis Rheum. 2012 Sep;64(9):2824-35. doi: 10.1002/art.34498.
3
Conventional combination treatment versus biological treatment in methotrexate-refractory early rheumatoid arthritis: 2 year follow-up of the randomised, non-blinded, parallel-group Swefot trial.
甲氨蝶呤耐药的早期类风湿关节炎的常规联合治疗与生物治疗：随机、非盲、平行组 Swefot 试验的 2 年随访。
Lancet. 2012 May 5;379(9827):1712-20. doi: 10.1016/S0140-6736(12)60027-0. Epub 2012 Mar 29.
4
EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs.EULAR 推荐的使用合成和生物疾病修饰抗风湿药物治疗类风湿关节炎的建议。
Ann Rheum Dis. 2010 Jun;69(6):964-75. doi: 10.1136/ard.2009.126532. Epub 2010 May 5.
5
Addition of infliximab compared with addition of sulfasalazine and hydroxychloroquine to methotrexate in patients with early rheumatoid arthritis (Swefot trial): 1-year results of a randomised trial.在早期类风湿关节炎患者中，与在甲氨蝶呤基础上加用柳氮磺吡啶和羟氯喹相比，加用英夫利昔单抗的疗效比较（Swefot试验）：一项随机试验的1年结果
Lancet. 2009 Aug 8;374(9688):459-66. doi: 10.1016/S0140-6736(09)60944-2.
6
Guidelines for initiation of anti-tumour necrosis factor therapy in rheumatoid arthritis: similarities and differences across Europe.类风湿关节炎中抗肿瘤坏死因子治疗起始指南：欧洲各地的异同
Ann Rheum Dis. 2009 Apr;68(4):456-9. doi: 10.1136/ard.2008.100362.
7
Comparison of treatment strategies in early rheumatoid arthritis: a randomized trial.早期类风湿关节炎治疗策略的比较：一项随机试验
Ann Intern Med. 2007 Mar 20;146(6):406-15. doi: 10.7326/0003-4819-146-6-200703200-00005.
8
Treatment of rheumatoid arthritis with methotrexate and hydroxychloroquine, methotrexate and sulfasalazine, or a combination of the three medications: results of a two-year, randomized, double-blind, placebo-controlled trial.甲氨蝶呤与羟氯喹、甲氨蝶呤与柳氮磺胺吡啶或三种药物联合治疗类风湿性关节炎：一项为期两年的随机、双盲、安慰剂对照试验的结果
Arthritis Rheum. 2002 May;46(5):1164-70. doi: 10.1002/art.10228.
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Comparison of combination therapy with single-drug therapy in early rheumatoid arthritis: a randomised trial. FIN-RACo trial group.早期类风湿关节炎联合治疗与单药治疗的比较：一项随机试验。芬兰类风湿关节炎联合治疗试验组
Lancet. 1999 May 8;353(9164):1568-73. doi: 10.1016/s0140-6736(98)08513-4.
10
Treatment of rheumatoid arthritis with methotrexate alone, sulfasalazine and hydroxychloroquine, or a combination of all three medications.单独使用甲氨蝶呤、柳氮磺胺吡啶和羟氯喹治疗类风湿性关节炎，或三种药物联合使用。
N Engl J Med. 1996 May 16;334(20):1287-91. doi: 10.1056/NEJM199605163342002.