Krutmann J
Leibniz-Institut für Umweltmedizinische Forschung an der Heinrich-Heine-Universität Düsseldorf gGmbH, Auf'm Hennekamp 50, 40225, Düsseldorf.
Hautarzt. 2011 Aug;62(8):588-90. doi: 10.1007/s00105-011-2132-y.
Extrinsic factors (= environmentally induced skin aging) lead to both epidermal and dermal changes. Recent investigations have shown that the dermis plays the decisive role, at least for skin aging caused by ultraviolet (UV) radiation. Exposure to UV radiation results in an accumulation of damage to the mitochondrial DNA of dermal fibroblasts and thus an altered gene expression of the affected cells, which chronically drives both the dermal (e.g., wrinkle formation) and epidermal (atrophy, barrier dysfunction) aging process. This knowledge is currently being used to develop highly effective cosmetic strategies to reverse the skin aging process.
外在因素（即环境诱导的皮肤老化）会导致表皮和真皮层的变化。最近的研究表明，真皮层至少在由紫外线（UV）辐射引起的皮肤老化过程中起着决定性作用。暴露于紫外线辐射会导致真皮成纤维细胞的线粒体DNA损伤积累，从而使受影响细胞的基因表达发生改变，长期推动真皮（如皱纹形成）和表皮（萎缩、屏障功能障碍）的老化过程。目前，这一知识正被用于开发高效的美容策略，以逆转皮肤老化过程。
