[流感的病因特异性治疗：上一次大流行的经验教训]
[Etiotropic therapy of influenza: lessons from the last pandemic].
作者信息
Kolobukhina L V, Shchelkanov M Iu, Merkulova L N, Bazarova M V, Burtseva E I, Samokhvalov E I, Al'khovskiĭ S V, Prilipov A G, Fediakina I T, Proshina E S, Aristova V A, Morozova T N, Sutochnikova O A, Ponomarenko R A, Malyshev N A, Maslov A M, Chuchalin A G
出版信息
Vestn Ross Akad Med Nauk. 2011(5):35-40.
Analysis of the experience gained during the last pandemic of 'swine' influenza A (H1N1) sw1 is presented with reference to clinical studies and etiotropic therapy. The mechanism of development of severe pneumonia as a result of mutations at the binding site of hemagglutinin receptor enhancing a2'-3'-sialoside specificity and pneumotropism of the virus is described. The data on the efficiency of Ingavirin, a new Russian antiviral for the treatment of influenza, are reported.
本文结合临床研究和病因导向治疗，对甲型H1N1“猪”流感（sw1）上一次大流行期间所获经验进行了分析。描述了血凝素受体结合位点发生突变导致严重肺炎的机制，该突变增强了病毒的α2'-3'-唾液酸苷特异性和气嗜性。报告了俄罗斯一种治疗流感的新型抗病毒药物英加韦林的疗效数据。
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