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[俄罗斯加利福尼亚脑炎血清群的虫媒病毒及其在感染性病理学中的作用]

[Arborviruses of the California encephalitis serogroup 1N Russia and their contribution to infectious pathology].

作者信息

Kolobukhina L V, L'vov S D

出版信息

Vestn Ross Akad Med Nauk. 2011(5):41-5.

Abstract

This review focuses on arborviral infections associated with California serocomplex (Bunyaviridae, Orthobunyavirus). Results of relevant eco-epidemiological and clinical studies in Russia are presented suggesting the ubiquitious nature of diseases caused by viruses of the California encephalitis serocomplex (Inko, Tahyna, Snowshoe Hare). The etiologic structure of these diseases in taiga and mixed woods of the European part and Western Siberia is dominated by the Inco virus and in southern regions by Tahina. The diseases have a well apparent seasonal pattern (July-August) in agreement with the peak summer activity of the pathogens. Two clinical forms of pathology are distinguished, influenza-like and generalized, the latter affecting lungs, kidneys, liver, and CNS. The Inco virus plays a key role in pathogenesis of the generalized form affecting CNS.

摘要

本综述聚焦于与加利福尼亚血清复合体(布尼亚病毒科,正布尼亚病毒属)相关的虫媒病毒感染。文中呈现了俄罗斯相关生态流行病学和临床研究的结果,表明由加利福尼亚脑炎血清复合体(因科病毒、塔希纳病毒、雪兔病毒)的病毒引起的疾病具有普遍性。在欧洲部分地区和西西伯利亚的泰加林和混交林中,这些疾病的病因结构以因科病毒为主,而在南部地区则以塔希纳病毒为主。这些疾病具有明显的季节性模式(7月至8月),与病原体在夏季的活动高峰期一致。病理学有两种临床形式,即流感样和全身性,后者会影响肺、肾、肝和中枢神经系统。因科病毒在影响中枢神经系统的全身性疾病的发病机制中起关键作用。

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