Kolomin T A, Shadrina M I, Slominskiĭ P A, Limborskaia S A, Miasoedov N F
Genetika. 2011 May;47(5):711-4.
A study of the immunomodulating effect of selank showed that the total peptide and its fragment significantly change the expression of the genes for chemokines, cytokines, and their receptors in mouse spleen 6 and 24 h after administration of a single dose. Changes in the mRNA level of the majority of the genes under study were similarly observed after the administration of Gly-Pro, which was earlier identified as a selank pharmacophor, a minimum fragment with anitiviral activity. Pharmacological preparations based on endogenous regulatory peptides are studied intensely because they are the most promising class of drugs and have almost no side effects. The class includes selank, which is a synthetic analog of taftsin. Selank exerts anxiolytic and nootropic effects and, on the other hand, has pronounced antiviral properties.
一项关于硒兰免疫调节作用的研究表明，总肽及其片段在单次给药后6小时和24小时可显著改变小鼠脾脏中趋化因子、细胞因子及其受体的基因表达。在给予甘氨酸-脯氨酸后，也观察到了大多数研究基因的mRNA水平发生类似变化，甘氨酸-脯氨酸此前被确定为硒兰药效基团，即具有抗病毒活性的最小片段。基于内源性调节肽的药物制剂正受到深入研究，因为它们是最有前景的一类药物，且几乎没有副作用。这类药物包括硒兰，它是塔夫辛的合成类似物。硒兰具有抗焦虑和益智作用，另一方面，还具有显著的抗病毒特性。
