Pediatric Research Center, University of Tampere and Tampere University Hospital, Tampere, Finland.
Int Rev Immunol. 2011 Aug;30(4):185-96. doi: 10.3109/08830185.2011.595854.
In celiac disease, highly sensitive and specific serum endomysial and transglutaminase 2 antibody tests are widely used in identifying patients for diagnostic endoscopy and small-bowel biopsy. In addition, the recently developed deamidated gliadin peptide antibody tests show promise in celiac disease diagnostics. In view of these apparent problems attending the diagnostic gold standard, gluten-induced small-bowel mucosal villous atrophy with crypt hyperplasia, other diagnostic approaches beyond conventional histology have been introduced. Furthermore, the diagnostic criteria for celiac disease are currently under revision with an eye also to noninvasive diagnostic strategies.
在乳糜泻中，高度敏感和特异的血清内膜和转谷氨酰胺酶 2 抗体检测广泛用于识别患者进行诊断性内镜和小肠活检。此外，最近开发的脱酰胺麦胶蛋白肽抗体检测在乳糜泻诊断中显示出前景。鉴于这些明显的问题伴随诊断的金标准，即麸质引起的小肠黏膜绒毛萎缩伴隐窝增生，除了传统组织学之外，还引入了其他诊断方法。此外，乳糜泻的诊断标准目前正在修订中，同时也着眼于非侵入性的诊断策略。
