College of Veterinary Medicine, Northeast Agricultural University, No. 59 Mucai Street, Xiangfang District, Harbin, 150030, China.
Environ Toxicol Pharmacol. 2011 Mar;31(2):295-301. doi: 10.1016/j.etap.2010.11.007. Epub 2010 Nov 27.
The toxic effects of exposure to aluminum (Al) in an acidic condition on bone formation in young growing rats were studied. Wistar rats were divided randomly into Al-treated group (100mg Al(3+)/L; pH 5.6) and control group (distilled water). Al-treated rats showed lower body weight, lower serum pH, higher accumulation of Al, in addition to disordered metabolism of calcium and phosphorus compared with control rats. The levels of parathyroid hormone, calcitonin, osteocalcin, procollagen carboxy-terminal propeptide and bone alkaline phosphatase were significantly lower in the Al-treated group than in the control group from days 90, 30, 60, 60 and 90, respectively. The bone mineral density of the distal and proximal femoral metaphysis was significantly lower in the Al-treated group than in the control group on days 120 and 150. These findings suggest that long-term Al exposure in an acidic condition inhibits bone formation and induces bone loss in young growing animals.
研究了在酸性条件下暴露于铝（Al）对幼年生长大鼠骨形成的毒性作用。Wistar 大鼠随机分为铝处理组（100mg Al(3+)/L；pH 5.6）和对照组（蒸馏水）。与对照组相比，铝处理组的大鼠体重较低，血清 pH 值较低，Al 积累较多，钙磷代谢紊乱。从第 90、30、60、60 和 90 天起，铝处理组的甲状旁腺激素、降钙素、骨钙素、前胶原羧基端肽和骨碱性磷酸酶水平明显低于对照组。第 120 和 150 天，铝处理组大鼠股骨远、近端干骺端骨密度明显低于对照组。这些发现表明，长期在酸性条件下暴露于铝会抑制幼年生长动物的骨形成并导致骨丢失。
