Division of Cardiovascular and Thoracic Surgery, Duke University, Durham, NC, USA.
J Thorac Cardiovasc Surg. 2012 Jan;143(1):111-7, 117.e1. doi: 10.1016/j.jtcvs.2011.05.006. Epub 2011 Jul 23.
Patients with coronary artery disease complicated by moderate ischemic mitral regurgitation have demonstrably poorer outcome than do patients with coronary artery disease but without mitral regurgitation. The optimal treatment of this condition has become increasingly controversial, and a randomized trial evaluating current practices is warranted.
We describe the design and initial execution of the Cardiothoracic Surgical Trials Network Surgical Interventions for Moderate Ischemic Mitral Regurgitation Trial.
This is an ongoing prospective, multicenter, randomized, controlled clinical trial designed to test the safety and efficacy of mitral repair in addition to coronary artery bypass grafting in the treatment of moderate ischemic mitral regurgitation.
The results of the Cardiothoracic Surgical Trials Network Surgical Interventions for Moderate Ischemic Mitral Regurgitation Trial will provide long-awaited information on controversial therapies for this morbid disease process.
患有中度缺血性二尖瓣反流的冠心病患者的预后明显差于没有二尖瓣反流的冠心病患者。这种情况的最佳治疗方法变得越来越有争议，有必要进行一项评估当前治疗方法的随机试验。
我们描述了心胸外科学术网络二尖瓣修复术治疗中度缺血性二尖瓣反流试验的设计和初步执行情况。
这是一项正在进行的前瞻性、多中心、随机、对照临床试验，旨在测试二尖瓣修复术联合冠状动脉旁路移植术治疗中度缺血性二尖瓣反流的安全性和疗效。
心胸外科学术网络二尖瓣修复术治疗中度缺血性二尖瓣反流试验的结果将为这种病态疾病过程的争议性治疗方法提供期待已久的信息。
