卷柏中新的 3'，8'-连接双黄酮类化合物具有抗缺氧保护作用。
New 3',8''-linked biflavonoids from Selaginella uncinata displaying protective effect against anoxia.
机构信息
Faculty of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China.
出版信息
Molecules. 2011 Jul 25;16(8):6206-14. doi: 10.3390/molecules16086206.
Seven 3',8''-linked bioflavonoids, including one new compound, (2''S)-2'', 3''-dihydroamentoflavone-4'-methyl ether and six known compounds: (2S)-2,3- dihydroamentoflavone-4'-methyl ether, (2S,2''S)-2,3,2'',3''-tetrahydroamento- flavone-4'-methyl ether, (2S,2''S)-tetrahydroamentoflavone, (2S)-2,3-dihydro- amentoflavone and (2''S)-2'',3''-dihydroamentoflavone (6) and amentoflavone, were isolated from the 60% ethanolic extract of Selaginella uncinata (Desv.) Spring. The structures of these compounds were elucidated mainly by analysis of their 1D and 2D NMR spectroscopic data, and their absolute configurations were determined by circular-dichroism (CD) spectroscopy. All the seven compounds showed protective effect against anoxia in the anoxic PC12 cells assay, in which compound 6 displayed particularly potent activity.
从卷柏（Desv.）的 60%乙醇提取物中分离得到了 7 种 3'，8'-连接的生物类黄酮，包括一种新化合物（2''S）-2''，3''-二氢阿替莫黄酮-4'-甲醚和 6 种已知化合物：（2S）-2,3-二氢阿替莫黄酮-4'-甲醚，（2S，2''S）-2,3,2'',3''-四氢阿替莫黄酮-4'-甲醚，（2S，2''S）-四氢阿替莫黄酮，（2S）-2,3-二氢阿替莫黄酮和（2''S）-2'',3''-二氢阿替莫黄酮（6）和阿替莫黄酮。这些化合物的结构主要通过分析它们的 1D 和 2D NMR 光谱数据来阐明，它们的绝对构型通过圆二色性（CD）光谱来确定。所有这 7 种化合物在缺氧 PC12 细胞测定中均显示出对缺氧的保护作用，其中化合物 6 表现出特别强的活性。
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