Department of Food Technology, University North, Trg Dr. Žarka Dolinara 1, HR-48000 Koprivnica, Croatia.
Laboratory for Plant Physiology, Department of Biology, Faculty of Science, University of Sarajevo, Zmaja od Bosne 33-35, 71 000 Sarajevo, Bosnia and Herzegovina.
Molecules. 2024 Sep 29;29(19):4634. doi: 10.3390/molecules29194634.
Dimeric forms of flavonoids, known as biflavonoids, are much less studied compared to monomeric forms. It is estimated that nearly 600 different natural biflavonoids have been described to date, containing various subtypes that can be subdivided according to the position of their combinations and the nature of the subunits. The group in which two monomers are linked by a 3'-8″-C atom includes the first isolated biflavonoid ginkgetin, derivatives of amentoflavone, and several other compounds. 3'-8″-biflavones recently attracted much attention as potential molecules with biological activity such as antiviral and antimicrobial activity and as effective molecules for the treatment of neurodegenerative and metabolic diseases and in cancer therapies. With the growing interest in them as pharmacologically active molecules, there is also increasing interest in finding new natural sources of 3'-8″-biflavones and optimizing methods for their extraction and identification. Herein, we have summarized the available data on the structural diversity, natural occurrence, role in plants, extraction, and identification of 3'-8″-biflavones.
二聚形式的类黄酮，被称为双黄酮，与单体形式相比，研究得较少。据估计，迄今为止已经描述了近 600 种不同的天然双黄酮，其中包含各种亚型，可根据它们的组合位置和亚基的性质进行细分。由 3'-8″-C 原子连接两个单体的基团包括第一个分离的双黄酮银杏素、amentoflavone 的衍生物和其他几种化合物。最近，3'-8″-双黄酮作为具有抗病毒和抗菌活性等生物活性的潜在分子以及治疗神经退行性和代谢疾病以及癌症治疗的有效分子引起了广泛关注。随着人们对它们作为药理活性分子的兴趣日益增加，人们也越来越关注寻找 3'-8″-双黄酮的新天然来源，并优化其提取和鉴定方法。在此，我们总结了有关 3'-8″-双黄酮的结构多样性、天然存在、在植物中的作用、提取和鉴定的现有数据。
