Niederkorn Jerry Y
Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Curr Immunol Rev. 2011 Aug;7(3):328-335. doi: 10.2174/157339511796196593.
The ocular surface is continuously exposed to environmental agents such as allergens, pollutants, and microorganisms, which could provoke inflammation. However, an array of anatomical, physiological, and immunological features of the ocular surface conspire to limit corneal inflammation and endow the eye with immune privilege. A remarkable example of ocular immune privilege is the success of corneal allografts, which unlike all other forms of organ transplantation, survive without the use of systemic immunosuppressive drugs or MHC matching. This review describes the anatomical, physiological, and dynamic immunoregulatory processes that contribute to immune privilege.
眼表持续暴露于环境因素，如过敏原、污染物和微生物，这些因素可能引发炎症。然而，眼表一系列的解剖学、生理学和免疫学特征共同作用，限制角膜炎症并赋予眼睛免疫赦免权。角膜移植成功是眼免疫赦免的一个显著例子，与所有其他器官移植形式不同，角膜移植无需使用全身性免疫抑制药物或进行MHC配型即可存活。本综述描述了有助于免疫赦免的解剖学、生理学和动态免疫调节过程。
