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激素治疗在前列腺癌管理中的应用：循证方法。

Hormone therapy in the management of prostate cancer: evidence-based approaches.

机构信息

Chairman, Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, 1025 Walnut Street, Suite 1112, Philadelphia, PA 19107, USA.

出版信息

Ther Adv Urol. 2010 Aug;2(4):171-81. doi: 10.1177/1756287210375270.

DOI:10.1177/1756287210375270
PMID:21789093
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3126080/
Abstract

Hormonal therapy has been the standard for advanced prostate cancer for over 60 years. Recently, the utility of androgen ablation through various means has been demonstrated for earlier stages of disease. In particular, the strongest evidence to date involves the use of hormonal therapy in combination with radiation therapy. In this article we review the basic concepts in hormonal ablation for prostate cancer and review the evidence-based studies that support the use of hormonal therapy in early stage prostate cancer.

摘要

激素治疗已经成为 60 多年来治疗晚期前列腺癌的标准方法。最近，通过各种手段进行雄激素阻断的方法在疾病早期阶段的应用也得到了证实。特别是，迄今为止最有力的证据涉及到联合使用激素治疗和放射治疗。在本文中，我们回顾了前列腺癌激素消融的基本概念，并回顾了支持在早期前列腺癌中使用激素治疗的基于证据的研究。

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本文引用的文献

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Androgen deprivation therapy and estrogen deficiency induced adverse effects in the treatment of prostate cancer.雄激素剥夺疗法和雌激素缺乏引起的不良反应在前列腺癌治疗中的作用。
Prostate Cancer Prostatic Dis. 2009;12(4):333-8. doi: 10.1038/pcan.2009.35. Epub 2009 Sep 1.
2
Benefit of whole pelvic radiotherapy combined with neoadjuvant androgen deprivation for the high-risk prostate cancer.全盆腔放疗联合新辅助雄激素剥夺治疗高危前列腺癌的益处。
J Biomed Biotechnol. 2009;2009:625394. doi: 10.1155/2009/625394. Epub 2009 Oct 22.
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Potential benefits of intermittent androgen suppression therapy in the treatment of prostate cancer: a systematic review of the literature.间歇性雄激素抑制疗法治疗前列腺癌的潜在益处：文献系统评价。
Eur Urol. 2010 Jan;57(1):49-59. doi: 10.1016/j.eururo.2009.07.049. Epub 2009 Aug 7.
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Long-term follow-up of 3-month neoadjuvant hormone therapy before radical prostatectomy in a randomized trial.根治性前列腺切除术前行 3 个月新辅助激素治疗的长期随访：一项随机试验。
BJU Int. 2010 Jan;105(2):185-90. doi: 10.1111/j.1464-410X.2009.08698.x. Epub 2009 Jul 8.
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Combined androgen blockade with bicalutamide for advanced prostate cancer: long-term follow-up of a phase 3, double-blind, randomized study for survival.比卡鲁胺联合雄激素阻断治疗晚期前列腺癌：一项关于生存情况的3期双盲随机研究的长期随访
Cancer. 2009 Aug 1;115(15):3437-45. doi: 10.1002/cncr.24395.
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Neoadjuvant androgen deprivation for prostate volume reduction: the optimal duration in prostate cancer radiotherapy.新辅助雄激素剥夺治疗前列腺体积缩小：前列腺癌放疗中的最佳持续时间。
Urol Oncol. 2011 Jan-Feb;29(1):52-7. doi: 10.1016/j.urolonc.2009.03.024. Epub 2009 Jun 12.
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Duration of androgen suppression in the treatment of prostate cancer.雄激素抑制在前列腺癌治疗中的持续时间。
N Engl J Med. 2009 Jun 11;360(24):2516-27. doi: 10.1056/NEJMoa0810095.
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Adjuvant hormone therapy for localised and locally advanced prostate carcinoma: a systematic review and meta-analysis of randomised trials.局限性和局部晚期前列腺癌的辅助激素治疗：随机试验的系统评价和荟萃分析
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