雄激素剥夺治疗期间的心血管和代谢并发症：运动作为一种潜在的应对措施。
Cardiovascular and metabolic complications during androgen deprivation: exercise as a potential countermeasure.
作者信息
Galvão D A, Taaffe D R, Spry N, Joseph D, Newton R U
机构信息
Vario Health Institute, School of Exercise, Biomedical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.
出版信息
Prostate Cancer Prostatic Dis. 2009;12(3):233-40. doi: 10.1038/pcan.2009.12. Epub 2009 Jun 2.
Apart from the well-established adverse musculoskeletal and sexual health effects of androgen deprivation therapy (ADT), evidence is accumulating of substantial ADT-related cardiovascular and metabolic complications, which may impact quality of life and overall survival. In this brief review we discuss (1) the incidence of cardiovascular and metabolic complications during/following ADT from large cohort studies, (2) the increased risk factors for cardiovascular and metabolic disease from cross-sectional and prospective studies and (3) the use of physical exercise as a countermeasure in this new era of ADT-related toxicity. It is clear that exercise has the potential to provide a myriad of benefits to men undergoing ADT that may result in reduced morbidity and mortality, and subsequently improve quality of life.
除了雄激素剥夺疗法（ADT）对肌肉骨骼和性健康已明确的不良影响外，越来越多的证据表明ADT还会引发大量心血管和代谢并发症，这可能会影响生活质量和总体生存率。在这篇简短的综述中，我们讨论了以下内容：（1）大型队列研究中ADT期间/之后心血管和代谢并发症的发生率；（2）横断面研究和前瞻性研究中导致心血管和代谢疾病的风险增加因素；（3）在这个ADT相关毒性的新时代，体育锻炼作为一种应对措施的应用。很明显，运动有可能为接受ADT的男性带来诸多益处，这可能会降低发病率和死亡率，进而改善生活质量。
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