Sayasneh Ahmad, Tsivos Dimitris, Crawford Robin
Department of Obstetrics & Gynaecology, The Rosie Hospital, Cambridge University Hospital NHS Trust, Hills Road, Cambridge CB2 2QQ, UK.
ISRN Obstet Gynecol. 2011;2011:140310. doi: 10.5402/2011/140310. Epub 2011 Jul 15.
Introduction. Endometriosis is one of the most common benign disorders which affects 10-15% of all women in reproductive age. The association between endometriosis and ovarian cancer has been frequently described in the medical literature. Purpose. To evaluate the literature for evidence of a correlation between endometriosis and ovarian cancer. Method. the English language literature (online MEDLINE and EMBASE database) was searched using the keywords endometriosis combined with cancer, tumour, tumor, carcinoma, or adenocarcinoma. All abstracts between January 1985 and August 2010 were reviewed. Full relevant articles were critically assessed. Reference lists of included studies were checked. Results. Seven out of the eight studies, included in our review, have shown an increased risk of ovarian cancer. However, the effect size is modest (OR, RR, and SIR) ranging between 1.32 and 1.9 (95% CI). A causative relationship between the two incidences cannot be confirmed. There is increasing evidence on the role of genetic mutations in ovarian clear-cell and endometrioid carcinoma developing from endometriosis. Conclusion. More evidence is needed before suggesting any change in the current management of endometriosis.
引言。子宫内膜异位症是最常见的良性疾病之一，影响10%至15%的育龄女性。医学文献中经常描述子宫内膜异位症与卵巢癌之间的关联。目的。评估文献中关于子宫内膜异位症与卵巢癌相关性的证据。方法。使用关键词子宫内膜异位症与癌症、肿瘤、癌或腺癌检索英文文献（在线MEDLINE和EMBASE数据库）。对1985年1月至2010年8月期间的所有摘要进行了审查。对所有相关全文进行了严格评估。检查了纳入研究的参考文献列表。结果。我们综述中纳入的八项研究中有七项显示卵巢癌风险增加。然而，效应大小适中（OR、RR和SIR），范围在1.32至1.9之间（95%CI）。无法确认这两种发病率之间的因果关系。越来越多的证据表明基因突变在由子宫内膜异位症发展而来的卵巢透明细胞癌和子宫内膜样癌中起作用。结论。在建议改变目前子宫内膜异位症的治疗方法之前，需要更多的证据。
