Department of Obstetrics and Gynecology, Center for Reproductive Medicine, Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine; The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Department of Clinical Medicine, The Third School of Clinical Medicine, Guangzhou Medical University, Guangzhou, 511436, China.
Sci Rep. 2024 Nov 18;14(1):28502. doi: 10.1038/s41598-024-79746-9.
Endometriosis is a chronic inflammatory disease and an estrogen-dependent disease, so dietary factors that can modulate estrogen activity may be clinically important. Dietary fiber, widely distributed in vegetables and fruits, is closely associated with a plant-based diet. Therefore, this study aims to analyze and explore the relationship between dietary fiber intake and the risk of endometriosis providing insights for future clinical significance and treatment approaches. This cross-sectional study obtained data from the National Health and Nutrition Examination Survey (NHANES) 1999-2006 for women aged 20-54 years. A total of 2840 subjects were finally included for analysis, 2599 (91.51%) in the non-endometriosis group and 241 (8.49%) in the endometriosis group. The study used dietary fibre intake as exposure variable and endometriosis risk as outcome variable. Through the use of multiple regression modelling, subgroup analyses, smoothed curve fitting, and threshold effect tests, we uncovered a significant link between exposure and outcome. In Model 2 (Multiple regression equation model after adjusting all confounding variables), after adjusting for confounders, dietary fiber intake was negatively associated with the likelihood of developing endometriosis(OR = 0.588, 95% CI = 0.360-0.959, p = 0.041). In subgroup analyses stratified by age, race, BMI, educational level, hypertension, diabetes,and hyperlipidemia, significant interactions were visualised from smoothed fitted curves. In the cross-sectional study, a connection was observed between a higher intake of dietary fiber and a decreased risk of endometriosis.
子宫内膜异位症是一种慢性炎症性疾病和雌激素依赖性疾病，因此可以调节雌激素活性的饮食因素可能具有重要的临床意义。膳食纤维广泛存在于蔬菜和水果中，与植物性饮食密切相关。因此，本研究旨在分析和探讨膳食纤维摄入与子宫内膜异位症风险之间的关系，为未来的临床意义和治疗方法提供见解。本横断面研究从 1999-2006 年全国健康和营养调查（NHANES）中获取了 20-54 岁女性的数据。最终共纳入 2840 名受试者进行分析，其中非子宫内膜异位症组 2599 名（91.51%），子宫内膜异位症组 241 名（8.49%）。本研究以膳食纤维摄入量为暴露变量，以子宫内膜异位症风险为结局变量。通过使用多回归模型、亚组分析、平滑曲线拟合和阈值效应检验，我们揭示了暴露与结局之间的显著关联。在模型 2（调整所有混杂变量后的多元回归方程模型）中，在调整混杂因素后，膳食纤维摄入量与子宫内膜异位症发生的可能性呈负相关（OR=0.588，95%CI=0.360-0.959，p=0.041）。在按年龄、种族、BMI、教育程度、高血压、糖尿病和高脂血症分层的亚组分析中，从平滑拟合曲线中可以看出显著的交互作用。在横断面研究中，观察到膳食纤维摄入量较高与子宫内膜异位症风险降低之间存在关联。
