氧化应激和抗氧化剂在年龄相关性黄斑变性发病机制中的作用。
The role of oxidative stress and antioxidants in the pathogenesis of age-related macular degeneration.
机构信息
Etimesgut Public Health Laboratory, Ankara, Turkey.
出版信息
Clinics (Sao Paulo). 2011;66(5):743-6. doi: 10.1590/s1807-59322011000500006.
Abstract
OBJECTIVE
To investigate the role of oxidant/antioxidant status and protein oxidation in the development of age-related macular degeneration.
METHOD
The activities of serum superoxide dismutase and glutathione peroxidase and the levels of serum malondialdehyde, advanced oxidation protein products, glutathione and vitamin C were measured in 25 patients with age-related macular degeneration and 25 control subjects without age-related macular degeneration.
RESULT
The malondialdehyde and advanced oxidation protein product levels in the serum were significantly higher in the age-related macular degeneration patient group than in the control group (p<0.05). The superoxide dismutase activity in the serum was significantly lower in the age-related macular degeneration patient group than in the control group (p<0.05). The levels of vitamin C and glutathione and the activity of glutathione peroxidase in the serum were unchanged between groups (p>0.05).
CONCLUSION
The results of the present study suggest that decreased effectiveness of the antioxidant defense system and increased oxidative stress may play a role in the pathogenesis of age-related macular degeneration.
摘要
目的
探讨氧化应激状态和蛋白质氧化在年龄相关性黄斑变性发病机制中的作用。
方法
检测 25 例年龄相关性黄斑变性患者和 25 例无年龄相关性黄斑变性对照者血清中超氧化物歧化酶和谷胱甘肽过氧化物酶的活性以及血清丙二醛、晚期氧化蛋白产物、谷胱甘肽和维生素 C 的水平。
结果
年龄相关性黄斑变性患者组血清丙二醛和晚期氧化蛋白产物水平显著高于对照组（p<0.05）。年龄相关性黄斑变性患者组血清中超氧化物歧化酶活性显著低于对照组（p<0.05）。血清中维生素 C、谷胱甘肽水平和谷胱甘肽过氧化物酶活性在两组间无变化（p>0.05）。
结论
本研究结果提示抗氧化防御系统功能降低和氧化应激增加可能在年龄相关性黄斑变性的发病机制中发挥作用。
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