Department of Neurology, The First Affiliated Hospital, China Medical University, Shenyang 110001, China.
J Nutr Health Aging. 2012 Mar;16(3):201-4. doi: 10.1007/s12603-011-0350-8.
To measure the oxidative and antioxidant biochemical parameters in the serum of Chinese patients with age-related macular degeneration (AMD) and in a similar age control group from the same area.
A case-control study.
56 AMD patients ( 21 early dry, 13 geographic atrophy and 22 wet form) and 34 normal subjects, similar for age and sex were studied.
Both groups completed a questionnaire about demographic characters and dieatry habit, and the levels of serum lipid peroxidation (malondialdehyde, MDA) and antioxidants parameters (vitamin C and E, the activities of superoxide dismutase--SOD, total antioxidant capacity--TAC ) were determined.
There was a significantly higher frequency of daily intake of fruit and legumes in controls than in AMD patients. There was a significantly increased serum MDA levels and SOD activities, and significantly decreased serum vitamin C and total antioxidant capacity in AMD patients as compared to controls. The intensity of lipid peroxidation was higher with the progression of AMD. There was not difference in serum vitamin E levels between AMD patients and controls.
Oxido-reduction disturbance may be involved in the pathogenesis of AMD. There is a significantly decreased antioxidant capacity in AMD patients.
测量来自同一地区的年龄相关性黄斑变性（AMD）患者和相似年龄对照组的血清氧化和抗氧化生化参数。
病例对照研究。
56 名 AMD 患者（21 名早期干性、13 名地理萎缩和 22 名湿性）和 34 名年龄和性别相似的正常对照者。
两组均完成关于人口统计学特征和饮食习惯的问卷，测定血清脂质过氧化（丙二醛，MDA）和抗氧化剂参数（维生素 C 和 E、超氧化物歧化酶活性-SOD、总抗氧化能力-TAC）的水平。
对照组每日摄入水果和豆类的频率明显高于 AMD 患者。与对照组相比，AMD 患者的血清 MDA 水平升高，SOD 活性升高，血清维生素 C 和总抗氧化能力降低。随着 AMD 的进展，脂质过氧化的强度增加。AMD 患者和对照组的血清维生素 E 水平无差异。
氧化还原失衡可能与 AMD 的发病机制有关。AMD 患者的抗氧化能力明显下降。
