Department of Oral Pathology, Oral Medicine and Periodontology, Faculty of Dentistry, University of Malaya, 50603, Kuala Lumpur, Malaysia.
Eur Arch Otorhinolaryngol. 2012 Mar;269(3):999-1004. doi: 10.1007/s00405-011-1712-x. Epub 2011 Jul 26.
Early detection of oral potentially malignant epithelial lesions (PMELs) is aimed at improving survival rates as carcinogenesis is a multistep process and prevention is possible if these lesions are detected at an early and reversible stage of the disease. A prospective clinical study aimed at determining the prevalence of bilateral 'mirror-image' oral PMELs was carried out. Sample consisted of 32 (53.3%) Indians, 23 (38.3%) Chinese, 4 (6.7%) Malays and one (1.7%) Nepalese. All had histopathological confirmation of their primary existing PMEL as inclusion criteria. A total of 70 primary lesions were detected. The most common PMEL found was oral lichen planus. Of these, 28 (46.7%) patients exhibited bilateral 'mirror-image' lesions (n = 42) either synchronously (n = 32/42) or metachronously (n = 10/42). The remaining 32 (53.3%) patients had normal-looking contralateral mucosa. Present findings suggest that patients presenting with oral PMELs are at greater risk of developing a second lesion, most probably in the contralateral 'mirror-image' site.
早期发现口腔潜在恶性上皮病变（PMEL）的目的是提高生存率，因为癌变是一个多步骤的过程，如果这些病变在疾病的早期和可逆阶段被发现，就可以预防。进行了一项旨在确定双侧“镜像”口腔 PMEL 患病率的前瞻性临床研究。样本包括 32 名（53.3%）印度人、23 名（38.3%）中国人、4 名（6.7%）马来人和 1 名（1.7%）尼泊尔人。所有患者均符合纳入标准，即存在经组织病理学证实的原发性 PMEL。共发现 70 个原发性病变。最常见的 PMEL 是口腔扁平苔藓。其中，28 名（46.7%）患者表现出双侧“镜像”病变（n = 42），无论是同步（n = 32/42）还是异时（n = 10/42）。其余 32 名（53.3%）患者对侧黏膜外观正常。目前的发现表明，出现口腔 PMEL 的患者发生第二处病变的风险更高，很可能在对侧“镜像”部位。
