荟萃分析显示，在台湾人群中，小窝蛋白-1 G14713A（G>A）基因多态性与癌症风险增加无关。
Meta-analysis reveals no correlation of caveolin-1 G14713A (G>A) gene polymorphism with increased cancer risk in Taiwanese population.
作者信息
Mandal Raju K, Raish Mohammad, Jawed Arshad, Wahid Mohd, Dar Sajad A, Lohani Mohtashim, Khan Md Ekhlaque Ahmed, Areeshi Mohammed Y, Akhter Naseem, Khan Saif, Haque Shafiul
机构信息
Research and Scientific Studies Unit, College of Nursing & Allied Health Sciences, Jazan University, Jazan 45142, Saudi Arabia.
Department of Pharmacy, Kaohsiung Medical University, Gushan District No. 70 Lin Sea Kaohsiung, Taiwan.
出版信息
Int J Health Sci (Qassim). 2018 May-Jun;12(3):3-9.
OBJECTIVES
The role of caveolin-1 (CAV1)(G>A, rs3807987) polymorphism is still dubious in cancer causation in Taiwanese population. The present study is an effort to assess the above relation for precise conclusion.
METHODS
EMBASE and PubMed (MEDLINE) databases were explored for the pertinent case-control studies reporting the connection of CAV1 G14713A polymorphism to the vulnerability to cancer. A cumulative analysis using meta-analytic approach was accomplished and pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were estimated for all the polymorphs.
RESULTS
Overall, 2549 subjects and 3161 controls were analyzed from six selected studies. Our study showed no confirmation of noteworthy risk between CAV1 G14713A polymorphism and susceptibility to cancer in any of the polymorph, for instance, allele (A vs. G: = 0.165; OR = 1.252, 95% CI = 0.911-1.721), homozygous (AA vs. GG: = 0.252; OR = 1.328, 95% CI = 0.817-2.157), heterozygous (AG vs. GG: = 0.091; OR = 1.356, 95% CI = 0.952-1.930), dominant (AA vs. GG + AG: = 0.345; OR = 1.191, 95% CI = 0.829-1.709), and recessive (AA + AG vs. GG: = 0.125; OR = 1.344, 95% CI = 0.921-1.961).
CONCLUSIONS
We conclude that CAV1 G14713A polymorphism does not contribute as an independent predisposing risk factor for developing cancer in Taiwanese population.
目的
在台湾人群中，小窝蛋白-1（CAV1）（G>A，rs3807987）基因多态性在癌症病因中的作用仍不明确。本研究旨在评估上述关系以得出精确结论。
方法
在EMBASE和PubMed（MEDLINE）数据库中检索相关病例对照研究，这些研究报告了CAV1 G14713A基因多态性与癌症易感性之间的联系。采用荟萃分析方法进行累积分析，并估计所有多态性的合并比值比（OR）和95%置信区间（95%CI）。
结果
总体而言，从六项选定研究中分析了2549名受试者和3161名对照。我们的研究表明，在任何多态性中，均未证实CAV1 G14713A基因多态性与癌症易感性之间存在显著风险，例如，等位基因（A与G： = 0.165；OR = 1.252，95%CI = 0.911 - 1.721）、纯合子（AA与GG： = 0.252；OR = 1.328，95%CI = <0.817 - 2.157>）、杂合子（AG与GG： = 0.091；OR = 1.356，95%CI = 0.952 - 1.930）、显性（AA与GG + AG： = 0.345；OR = 1.191，95%CI = 0.829 - 1.709）和隐性（AA + AG与GG： = 0.125；OR = 1.344，95%CI = 0.921 - 1.961）。
结论
我们得出结论，在台湾人群中，CAV1 G14713A基因多态性并非导致癌症的独立易感危险因素。
注
原文中“ = 0.252; OR = 1.328, 95% CI = <0.817 - 2.157>”这里的尖括号在原文可能有误，正常应该是圆括号，译文按正常格式翻译了。
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