Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
J Am Chem Soc. 2013 Mar 6;135(9):3387-90. doi: 10.1021/ja400648w. Epub 2013 Feb 25.
The alkynylation of β-C(sp(3))-H bonds in aliphatic amides with alkynyl halides has been enabled using Pd(0)/N-heterocyclic carbene (NHC) and Pd(0)/phosphine (PR3) catalysts. This is the first example of utilizing [AlkynylPd(II)L(n)] complexes to activate C(sp(3))-H bonds.
使用钯 (0)/氮杂环卡宾 (NHC) 和钯 (0)/膦 (PR3) 催化剂，实现了脂肪酰胺中β-C(sp(3))-H 键与炔基卤化物的炔基化反应。这是首次利用[炔基 Pd(II)L(n)]配合物来活化 C(sp(3))-H 键。
